, Volume 8, Issue 1, pp 20-22
Date: 23 Dec 2011

Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis

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Introduction

Synovitis (inflammation of the synovial lining) is increasingly recognized as a characteristic of the osteoarthritic joint. Over the past decade, many have documented that synovitis is present in various stages of the disease and is detectable by advanced imaging techniques [3], the presence of soluble mediators [5], or histopathologic assessment [9]. Despite using different methods of detection and different outcome measurements, studies from these multiple research groups have often led to similar conclusions.

Synovitis and Clinical Severity of OA

Synovial inflammation detectable by magnetic resonance imaging (MRI) [3] or histopathologic analysis of synovial tissues [11] is associated with greater levels of pain and joint symptoms in osteoarthritis (OA) and post-injury patients. A recent systematic review of MRI investigation of knee osteoarthritis suggested that this relationship is moderate to strong [4]. Consistent with the imaging studies, Ishijima et al. demonstrated t ...