Forensic Toxicology

, Volume 32, Issue 1, pp 9–18

Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-α-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products

  • Nahoko Uchiyama
  • Satoru Matsuda
  • Maiko Kawamura
  • Ruri Kikura-Hanajiri
  • Yukihiro Goda
Original Article

DOI: 10.1007/s11419-013-0194-5

Cite this article as:
Uchiyama, N., Matsuda, S., Kawamura, M. et al. Forensic Toxicol (2014) 32: 9. doi:10.1007/s11419-013-0194-5

Abstract

We identified two new-type designer drugs, piperazine derivative MT-45 [1-cyclohexyl-4-(1,2-diphenylethyl)piperazine, synonym: I-C6, 1] and synthetic peptide Noopept [ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate, synonym: GVS-111, 2], in chemical and herbal products. MT-45 (1) was previously reported as an opiate-like analgesic substance, and Noopept (2) was reported to have nootropic (cognitive enhancer) activity. We also detected two synthetic cannabinoids, A-834735 (3) and QUPIC N-(5-fluoropentyl) analog (synonym: 5-fluoro-PB-22, 4), in the illegal products. A-834735 (3) was previously reported to act as an agonist at both cannabinoid CB1 and CB2 receptors. In addition, cathinone derivative 4-methoxy-α-pyrrolidinovalerophenone (4-methoxy-α-PVP, 5) and phenethylamine derivative 4-methylbuphedrine (6) were newly detected with known cathinone derivative 4-methylbuphedrone (7) in the products.

Keywords

MT-45 [1-cyclohexyl-4-(1,2-diphenylethyl)piperazine, synonym: I-C6] Noopept [ethyl 2-(1-(2-phenylacetyl)pyrrolidine-2-carboxamido)acetate, synonym: GVS-111] A-834735 4-Methoxy-α-PVP 4-Methylbuphedrine QUPIC N-(5-fluoropentyl) analog (synonym: 5-fluoro-PB-22) 

Copyright information

© Japanese Association of Forensic Toxicology and Springer Japan 2013

Authors and Affiliations

  • Nahoko Uchiyama
    • 1
  • Satoru Matsuda
    • 1
  • Maiko Kawamura
    • 1
  • Ruri Kikura-Hanajiri
    • 1
  • Yukihiro Goda
    • 1
  1. 1.National Institute of Health SciencesSetagaya-kuJapan