Journal of Natural Medicines

, Volume 70, Issue 2, pp 217–224

In vitro and in vivo antiherpetic effects of (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol

  • Kohei Sasaki
  • Kyoko Hayashi
  • Yuji Matsuya
  • Kenji Sugimoto
  • Jung-Bum Lee
  • Fumiya Kurosaki
  • Toshimitsu Hayashi
Original Paper

DOI: 10.1007/s11418-016-0964-6

Cite this article as:
Sasaki, K., Hayashi, K., Matsuya, Y. et al. J Nat Med (2016) 70: 217. doi:10.1007/s11418-016-0964-6

Abstract

In this study, we demonstrated the in vitro and in vivo antiherpetic activities of a stable furan derivative, (1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol (MFPT), which had originally been isolated from Streptomyces sp. strain FV60. In the present study, we synthesized MFPT from (5-methylfuran-3-yl)methanol in 6 steps for use in the experiments. MFPT showed potent in vitro antiviral activities against two acyclovir (ACV)-sensitive (KOS and HF) strains and an ACV-resistant (A4-3) strain of herpes simplex virus type 1 (HSV-1) and an ACV-sensitive HSV type 2 (HSV-2) UW 268 strain, their selectivity indices ranging from 310 to 530. By intravaginal application of MFPT to mice, the virus yields decreased dose-dependently against the three strains of HSV-1 and HSV-2. When MFPT was applied at a dose of 1.0 mg/day, the lesion scores, as clinical signs manifested by viral infection, were extensively suppressed in HSV-1-infected mice, whereas the lesion scores in HSV-2-infected mice were not markedly decreased. Interestingly, MFPT exerted an inhibitory effect against ACV-resistant HSV-1 in mice to a similar degree as in ACV-sensitive HSV-1-infected mice. Therefore, the compound might have potential for developing a topical antiviral agent that could be also applied to the infections caused by ACV-resistant viruses.

Keywords

(1R,2R)-1-(5′-methylful-3′-yl)propane-1,2,3-triol (MFPT)Herpes simplex virus type 1Herpes simplex virus type 2Antiherpetic activityIntravaginal application

Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2016

Authors and Affiliations

  • Kohei Sasaki
    • 1
  • Kyoko Hayashi
    • 2
  • Yuji Matsuya
    • 1
  • Kenji Sugimoto
    • 1
  • Jung-Bum Lee
    • 1
  • Fumiya Kurosaki
    • 1
  • Toshimitsu Hayashi
    • 2
  1. 1.Graduate School of Medicine and Pharmaceutical Sciences for ResearchUniversity of ToyamaToyamaJapan
  2. 2.Research Institute of Life and Health SciencesChubu UniversityKasugaiJapan