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Phylogenetic examination of crude drugs derived from Yunnanese Swertia plants

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Abstract

Aiming to examine whether the genetic background of the crude drugs derived from four Yunnanese Swertia plants and their chemical constituent profiles correlate, we analyzed the nucleotide sequences of their nuclear ribosomal DNA regions including ITS1, 5.8S ribosomal RNA gene, and ITS2, together with those of Japanese S. japonica and S. pseudochinensis from Hebei Province. The result that two of the Yunnanese Swertia plants, S. binchuanensis and S. punicea, were genetically similar may explain their similarity in chemical constituent profiles. On the other hand, in spite of differences in chemical profile, S. decora and S. pseudochinensis were genetically close. The other Yunnanese Swertia plants, S. delavayi, and S. japonica, stood at intermediate positions between these two genetically similar pairs. The result suggests that although genetic background would have an influence, environmental factors, e.g., soil and weather conditions, might be critical for their production of secondary metabolites.

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  1. Nobuko Kakiuchi

    Present address: School of Pharmaceutical Sciences, Kyusyu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka, Miyazaki, 882-8508, Japan

Authors and Affiliations

  1. School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakumacho, Kanazawa, 920-1192, Japan

    Nobuko Kakiuchi, Naoko Iwaki & Masayuki Mikage

  2. Department of Pharmacy, Dali University, Dali, 671000, Yunnan Province, China

    Huai Xiao

  3. Division of Metabolic Engineering, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan

    Zhigang Wang & Masao Hattori

Authors
  1. Nobuko Kakiuchi
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  2. Naoko Iwaki
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  3. Masayuki Mikage
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  4. Huai Xiao
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  5. Zhigang Wang
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  6. Masao Hattori
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Correspondence to Nobuko Kakiuchi.

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Kakiuchi, N., Iwaki, N., Mikage, M. et al. Phylogenetic examination of crude drugs derived from Yunnanese Swertia plants. J Nat Med 68, 206–210 (2014). https://doi.org/10.1007/s11418-013-0776-x

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  • DOI: https://doi.org/10.1007/s11418-013-0776-x

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