Original Paper

Journal of Natural Medicines

, Volume 67, Issue 3, pp 590-598

New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity

  • Akihito YokosukaAffiliated withDepartment of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences Email author 
  • , Kenichi TakagiAffiliated withDepartment of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
  • , Yoshihiro MimakiAffiliated withDepartment of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

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Abstract

Six new cholestane glycosides (1, 5, 6, 10, 12, and 13) and two new sterols (9 and 11), along with five known compounds (24, 7, and 8), were isolated from the underground parts of Chamaelirium luteum (Liliaceae). The structures of these new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds and aglycones were evaluated for their cytotoxic activity against HL-60 human leukemia cells. Compounds 6a, 10a, 12a, 13, and 13a were cytotoxic to HL-60 cells, with IC50 values of 12.8, 9.8, 15.3, 6.2, and 10.2 µM, respectively.

Keywords

Chamaelirium luteum Liliaceae Cholestane glycosides Cytotoxic activity HL-60 cells