Journal of Natural Medicines

, Volume 67, Issue 3, pp 590–598

New cholestane glycosides and sterols from the underground parts of Chamaelirium luteum and their cytotoxic activity

  • Akihito Yokosuka
  • Kenichi Takagi
  • Yoshihiro Mimaki
Original Paper

DOI: 10.1007/s11418-012-0718-z

Cite this article as:
Yokosuka, A., Takagi, K. & Mimaki, Y. J Nat Med (2013) 67: 590. doi:10.1007/s11418-012-0718-z

Abstract

Six new cholestane glycosides (1, 5, 6, 10, 12, and 13) and two new sterols (9 and 11), along with five known compounds (24, 7, and 8), were isolated from the underground parts of Chamaelirium luteum (Liliaceae). The structures of these new compounds were determined by spectroscopic analysis and the results of hydrolytic cleavage. The isolated compounds and aglycones were evaluated for their cytotoxic activity against HL-60 human leukemia cells. Compounds 6a, 10a, 12a, 13, and 13a were cytotoxic to HL-60 cells, with IC50 values of 12.8, 9.8, 15.3, 6.2, and 10.2 µM, respectively.

Keywords

Chamaelirium luteumLiliaceaeCholestane glycosidesCytotoxic activityHL-60 cells

Copyright information

© The Japanese Society of Pharmacognosy and Springer Japan 2012

Authors and Affiliations

  • Akihito Yokosuka
    • 1
  • Kenichi Takagi
    • 1
  • Yoshihiro Mimaki
    • 1
  1. 1.Department of Medicinal Pharmacognosy, School of PharmacyTokyo University of Pharmacy and Life SciencesHachiojiJapan