Journal of Natural Medicines

, Volume 66, Issue 4, pp 614–621

Tumor specific cytotoxicity of arctigenin isolated from herbal plant Arctium lappa L.

Authors

  • Siti Susanti
    • United Graduate School of Agricultural SciencesKagoshima University
    • Center of Molecular Biosciences, Tropical Biosphere Research CenterUniversity of the Ryukyus
  • Hironori Iwasaki
    • Center of Molecular Biosciences, Tropical Biosphere Research CenterUniversity of the Ryukyus
  • Yukiyoshi Itokazu
    • Department of AgricultureUniversity of the Ryukyus
  • Mariko Nago
    • Department of AgricultureUniversity of the Ryukyus
  • Naoyuki Taira
    • Department of AgricultureUniversity of the Ryukyus
  • Seikoh Saitoh
    • Center of Molecular Biosciences, Tropical Biosphere Research CenterUniversity of the Ryukyus
    • Center of Molecular Biosciences, Tropical Biosphere Research CenterUniversity of the Ryukyus
Original Paper

DOI: 10.1007/s11418-012-0628-0

Cite this article as:
Susanti, S., Iwasaki, H., Itokazu, Y. et al. J Nat Med (2012) 66: 614. doi:10.1007/s11418-012-0628-0

Abstract

The effectiveness of cancer chemotherapy is often limited by the toxicity to other tissues in the body. Therefore, the identification of non-toxic chemotherapeutics from herbal medicines remains to be an attractive goal to advance cancer treatments. This study evaluated the cytotoxicity profiles of 364 herbal plant extracts, using various cancer and normal cell lines. The screening found occurrence of A549 (human lung adenocarcinoma) specific cytotoxicity in nine species of herbal plants, especially in the extract of Arctium lappa L. Moreover, purification of the selective cytotoxicity in the extract of Arctium lappa L. resulted in the identification of arctigenin as tumor specific agent that showed cytotoxicity to lung cancer (A549), liver cancer (HepG2) and stomach cancer (KATO III) cells, while no cytotoxicity to several normal cell lines. Arctigenin specifically inhibited the proliferation of cancer cells, which might consequently lead to the induction of apoptosis. In conclusion, this study found that arctigenin was one of cancer specific phytochemicals, and in part responsible for the tumor selective cytotoxicity of the herbal medicine.

Keywords

Tumor Herbal Extract Cytotoxicity Arctigenin

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2012