Journal of Natural Medicines

, Volume 65, Issue 3, pp 417–423

Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25–35)-induced neuritic atrophy in cultured rat cortical neurons

Authors

  • Yanjing Bai
    • Division of Pharmacognosy, Institute of Natural MedicineUniversity of Toyama
  • Chihiro Tohda
    • Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural MedicineUniversity of Toyama
  • Shu Zhu
    • Division of Pharmacognosy, Institute of Natural MedicineUniversity of Toyama
  • Masao Hattori
    • Division of Pharmacognosy, Institute of Natural MedicineUniversity of Toyama
    • Division of Pharmacognosy, Institute of Natural MedicineUniversity of Toyama
Original Paper

DOI: 10.1007/s11418-011-0509-y

Cite this article as:
Bai, Y., Tohda, C., Zhu, S. et al. J Nat Med (2011) 65: 417. doi:10.1007/s11418-011-0509-y

Abstract

Not only neuronal death but also neuritic atrophy and synaptic loss underlie the pathogenesis of Alzheimer’s disease as direct causes of the memory deficit. Extracts of Siberian ginseng (the rhizome of Eleutherococcus senticosus) were shown to have protective effects on the regeneration of neurites and the reconstruction of synapses in rat cultured cortical neurons damaged by amyloid β (Aβ)(25–35), and eleutheroside B was one of the active constituents. In this study, a comprehensive evaluation of constituents was conducted to explore active components from Siberian ginseng which can protect against neuritic atrophy induced by Aβ(25–35) in cultured rat cortical neurons. The ethyl acetate, n-butanol and water fractions from the methanol extract of Siberian ginseng showed protective effects against Aβ-induced neuritic atrophy. Twelve compounds were isolated from the active fractions and identified. Among them, eleutheroside B, eleutheroside E and isofraxidin showed obvious protective effects against Aβ(25–35)-induced atrophies of axons and dendrites at 1 and 10 μM.

Keywords

Siberian ginsengEleutherococcus senticosusAmyloid βNeuritic atrophyEleutheroside BEleutheroside E

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2011