Journal of Natural Medicines

, Volume 65, Issue 1, pp 37–42

Constituents with α-glucosidase and advanced glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge.

  • Hai-Ying Ma
  • Hui-Yuan Gao
  • Lu Sun
  • Jian Huang
  • Xiao-Min Xu
  • Li-Jun Wu
Original Paper

DOI: 10.1007/s11418-010-0453-2

Cite this article as:
Ma, HY., Gao, HY., Sun, L. et al. J Nat Med (2011) 65: 37. doi:10.1007/s11418-010-0453-2

Abstract

The 75% ethanol extract from roots of Salvia miltiorrhiza Bge. (Dan shen) afforded two new compounds, 3-hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione (1), (8′R)-isosalvianolic acid C methyl ester (2), and 14 known compounds. Their structures were established on the basis of spectral analysis. The ability of the compounds to inhibit α-glucosidase activity and formation of advanced glycation end-products (AGEs) was evaluated. All compounds displayed various degrees of inhibitory effects against α-glucosidase; moreover, compounds 2, 6, 11, 14, and 16 exhibited much more potent inhibition against AGEs than the positive control (aminoguanidine, AG, IC50 0.11 μM). This is the first time that compounds from this plant have been reported to have inhibitory activity against α-glucosidase.

Keywords

Salvia miltiorrhiza3-Hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione(8′R)-isosalvianolic acid C methyl esterα-GlucosidaseAGE product

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2010

Authors and Affiliations

  • Hai-Ying Ma
    • 1
  • Hui-Yuan Gao
    • 2
  • Lu Sun
    • 2
  • Jian Huang
    • 2
  • Xiao-Min Xu
    • 2
  • Li-Jun Wu
    • 2
  1. 1.Pharmacy DepartmentThe Fourth Affiliated Hospital of China Medical UniversityShenyangChina
  2. 2.School of Traditional Chinese MedicinesShenyang Pharmaceutical UniversityShenyangChina