Original Paper

Journal of Natural Medicines

, Volume 65, Issue 1, pp 37-42

First online:

Constituents with α-glucosidase and advanced glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge.

  • Hai-Ying MaAffiliated withPharmacy Department, The Fourth Affiliated Hospital of China Medical University Email author 
  • , Hui-Yuan GaoAffiliated withSchool of Traditional Chinese Medicines, Shenyang Pharmaceutical University
  • , Lu SunAffiliated withSchool of Traditional Chinese Medicines, Shenyang Pharmaceutical University
  • , Jian HuangAffiliated withSchool of Traditional Chinese Medicines, Shenyang Pharmaceutical University
  • , Xiao-Min XuAffiliated withSchool of Traditional Chinese Medicines, Shenyang Pharmaceutical University
  • , Li-Jun WuAffiliated withSchool of Traditional Chinese Medicines, Shenyang Pharmaceutical University

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

The 75% ethanol extract from roots of Salvia miltiorrhiza Bge. (Dan shen) afforded two new compounds, 3-hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione (1), (8′R)-isosalvianolic acid C methyl ester (2), and 14 known compounds. Their structures were established on the basis of spectral analysis. The ability of the compounds to inhibit α-glucosidase activity and formation of advanced glycation end-products (AGEs) was evaluated. All compounds displayed various degrees of inhibitory effects against α-glucosidase; moreover, compounds 2, 6, 11, 14, and 16 exhibited much more potent inhibition against AGEs than the positive control (aminoguanidine, AG, IC50 0.11 μM). This is the first time that compounds from this plant have been reported to have inhibitory activity against α-glucosidase.

Keywords

Salvia miltiorrhiza 3-Hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione (8′R)-isosalvianolic acid C methyl ester α-Glucosidase AGE product