Journal of Natural Medicines

, Volume 64, Issue 4, pp 417–422

Cytotoxic, radical scavenging and antimicrobial activities of sesquiterpenoids from the Tahitian liverwort Mastigophora diclados (Brid.) Nees (Mastigophoraceae)

  • Ismiarni Komala
  • Takuya Ito
  • Fumihiro Nagashima
  • Yasuyuki Yagi
  • Yoshinori Asakawa
Original Paper

DOI: 10.1007/s11418-010-0423-8

Cite this article as:
Komala, I., Ito, T., Nagashima, F. et al. J Nat Med (2010) 64: 417. doi:10.1007/s11418-010-0423-8

Abstract

A drimane, (+)-drimenol (1), five known herbertanes, (−)-α-herbertenol (2), (−)-herbertenediol (3), mastigophorene A (4), (−)-mastigophorene C (5) and (−)-mastigophorene D (6), a pimarane, (−)-ent-pimara-8(14),15-dien-19-oic acid (7), and two eudesmanolides, (−)-diplophyllolide A (8) and (−)-diplophyllin (9) were isolated from the Tahitian Mastigophora diclados (Brid.) Nees. Herbertane sesquiterpenes (2, 3, 5 and 6) showed cytotoxicity against HL-60 and KB cell lines, radical scavenging activity and antimicrobial activity against Bacillus subtilis. (−)-Diplophyllolide A (8) also exhibited cytotoxicity against HL-60 and KB cell lines.

Keywords

LiverwortMastigophora dicladosSesquiterpenoidCytotoxicityRadical scavengingAntimicrobial activity

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2010

Authors and Affiliations

  • Ismiarni Komala
    • 1
    • 2
  • Takuya Ito
    • 1
  • Fumihiro Nagashima
    • 1
  • Yasuyuki Yagi
    • 1
  • Yoshinori Asakawa
    • 1
  1. 1.Faculty of Pharmaceutical SciencesTokushima Bunri UniversityTokushimaJapan
  2. 2.Pharmacy Department, Faculty of Medicine and Health SciencesSyarif Hidayatullah State Islamic UniversityJakartaIndonesia