Journal of Natural Medicines

, Volume 64, Issue 3, pp 365–369

Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood

Authors

    • Faculty of PharmacyUniversiti Kebangsaan Malaysia
  • Yusyila H. Mohd Yasin
    • Faculty of PharmacyUniversiti Kebangsaan Malaysia
  • Shajarahtunnur Jamil
    • Department of Chemistry, Faculty of ScienceUniversiti Teknologi Malaysia
  • Hasnah Sirat
    • Department of Chemistry, Faculty of ScienceUniversiti Teknologi Malaysia
  • Norazah Basar
    • Department of Chemistry, Faculty of ScienceUniversiti Teknologi Malaysia
Note

DOI: 10.1007/s11418-010-0410-0

Cite this article as:
Jantan, I., Mohd Yasin, Y.H., Jamil, S. et al. J Nat Med (2010) 64: 365. doi:10.1007/s11418-010-0410-0

Abstract

Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC50 value of 100.9 μM. It also showed strong inhibition against ADP-induced aggregation, with an IC50 value of 57.1 μM. Isobavachalcone, 2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC50 values ranging from 55.3 to 192.0 μM, but did not show such effect against other inducers.

Keywords

Artocarpus speciesAntiplatelet aggregationHuman whole bloodCycloheterophyllin2′,4′-dihydroxy-4-methoxy-3′-prenyldihydrochalconeArachidonic acid

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2010