Natural Medicine Note

Journal of Natural Medicines

, Volume 63, Issue 1, pp 102-104

First online:

Sesquiterpenes from Curcuma comosa

  • Yang QuAffiliated withSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
  • , Fengming XuAffiliated withKyoto Pharmaceutical University
  • , Seikou NakamuraAffiliated withKyoto Pharmaceutical University
  • , Hisashi MatsudaAffiliated withKyoto Pharmaceutical University
  • , Yutana PongpiriyadachaAffiliated withRajamangala University of Technology Srivijaya
  • , Lijun WuAffiliated withSchool of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University
  • , Masayuki YoshikawaAffiliated withKyoto Pharmaceutical University Email author 

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From the dried rhizomes of Curcuma comosa cultivating in Thailand, 26 known sesquiterpenes were isolated: zederone, zederone epoxide, furanodienone, isofuranodienone, 1(10)Z,4Z-furanodiene-6-one, glechomanolide, dehydrocurdione, neocurdione, curdione, 7α-hydroxyneocurdione, 7β-hydroxycurdione, germacrone-1(10),4-diepoxide, germacrone, 13-hydroxygermacrone, curzerenone, curcolonol, alismol, alismoxide, zedoarondiol, isozedoarondiol, procurcumenol, isoprocurcumenol, aerugidiol, zedoalactone B, curcumenone, and curcumadione. Their structures were elucidated on the basis of physicochemical evidence. Among them, glechomanolide, curzerenone, curcolonol, alismol, alismoxide, and zedoarondiol showed no significant optical activities, so they may be artifact products during the isolation or drying process.


Curcuma comosa Zingiberaceae Sesquiterpenes