Journal of Natural Medicines

, 62:396

Antidiarrhoeal activity of the standardised extract of Cinnamomum tamala in experimental rats

Authors

    • Pharmacognosy and Ethnopharmacology DivisionNational Botanical Research Institute
  • Madhavan Vijayakumar
    • Pharmacognosy and Ethnopharmacology DivisionNational Botanical Research Institute
  • K. Sairam
    • Department of PharmaceuticsInstitute of Technology, Banarus Hindu University
  • Vikas Kumar
    • Department of PharmaceuticsInstitute of Technology, Banarus Hindu University
Original Paper

DOI: 10.1007/s11418-008-0258-8

Cite this article as:
Rao, C.V., Vijayakumar, M., Sairam, K. et al. J Nat Med (2008) 62: 396. doi:10.1007/s11418-008-0258-8

Abstract

The present study was designed to investigate the antidiarrhoeal potential of 50% ethanolic extract of Cinnamomum tamala on experimentally induced castor oil diarrhoea, gastric emptying of phenol red meal, gastrointestinal transit of charcoal meal and in vitro mast cell degranulation activity. C. tamala extract (25, 50 and 100 mg/kg, orally) produced a dose-dependent reduction in the total amount of faecal matter in castor oil-induced diarrhoea. The mean distance travelled by charcoal meal at 50 and 100 mg/kg of extract showed a significant reduction in the secretion of gastrointestinal fluid accumulation by 32.5–65.0%. The Na+ and K+ concentrations on castor oil-induced fluid accumulation showed a greater inhibitory effect on Na+ levels than on K+ concentrations. C. tamala significantly reduced the lipid peroxidation (P < 0.001) and increased the catalase (P < 0.01) activity in comparison to the castor oil-induced groups. C. tamala leaf extract did not show any significant effect at a higher dose (15 mg/ml) on mast cell degranulation. However, the extract in the dose of 5 and 10 mg/ml conferred significant mast cell protective action (P < 0.001). The percentage of eugenol in extract is 3.8% w/w, and total tannin is 247.5 mg/g. The result indicates the Indian spice C. tamala is useful for diarrhoea.

Keywords

Cinnamomum tamalaAntidiarrhoealIndian spice

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2008