Journal of Natural Medicines

, Volume 62, Issue 3, pp 284–293

Antihyperglycemic and antioxidative potential of Matricaria chamomilla L. in streptozotocin-induced diabetic rats

  • Mustafa Cemek
  • Sadık Kağa
  • Nejdet Şimşek
  • Mehmet Emin Büyükokuroğlu
  • Muhsin Konuk
Original Paper

DOI: 10.1007/s11418-008-0228-1

Cite this article as:
Cemek, M., Kağa, S., Şimşek, N. et al. J Nat Med (2008) 62: 284. doi:10.1007/s11418-008-0228-1

Abstract

Plants with antidiabetic activities provide important sources for the development of new drugs in the treatment of diabetes mellitus. In the present study, we investigated possible antihyperglycemic and antioxidative activities of the aerial part of the Matricaria chamomilla L. ethanolic extract (MCE) in streptozotocin (STZ; 70 mg/kg, i.p.)-induced diabetic rats. The following groups were assigned; sham (did not receive any substance), STZ + distilled water (control), STZ + 5 mg/kg glibenclamide, STZ + 20 mg/kg MCE, STZ + 50 mg/kg MCE, STZ + 100 mg/kg MCE. Diabetic rats were treated for 14 days by gavage. Postprandial blood glucose levels, malondialdehyde, reduced glutathione (GSH), nitrate, nitrite, ascorbic acid, retinol, β-carotene, superoxide dismutase, and catalase levels were measured, and immunohistochemical studies were performed in all of the groups. The obtained data showed that STZ resulted in oxidative stress and affected the antioxidant status. Treatment with different doses of MCE significantly reduced postprandial hyperglycemia and oxidative stress, and augmented the antioxidant system. In histological investigations, MCE treatment protected the majority of the pancreatic islet cells, with respect to the control group. As a result, MCE exhibited significant antihyperglycemic effect and protected β-cells in STZ-diabetic rats, in a dose-dependent manner, and diminished the hyperglycemia-related oxidative stress.

Keywords

Streptozotocin Diabetes Oxidative stress Antioxidant Pancreas Immunohistochemistry 

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2008

Authors and Affiliations

  • Mustafa Cemek
    • 1
  • Sadık Kağa
    • 1
  • Nejdet Şimşek
    • 2
  • Mehmet Emin Büyükokuroğlu
    • 3
  • Muhsin Konuk
    • 4
  1. 1.Department of Chemistry (Biochemistry Division), Faculty of Sciences and ArtsAfyon Kocatepe UniversityAfyonkarahisarTurkey
  2. 2.Department of Histology and Embriyology, Faculty of Veterinary MedicineAtatürk UniversityErzurumTurkey
  3. 3.Department of Pharmacology, Faculty of MedicineAfyon Kocatepe UniversityAfyonkarahisarTurkey
  4. 4.Department of Biology, Faculty of Sciences and ArtsAfyon Kocatepe UniversityAfyonkarahisarTurkey

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