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Journal of Natural Medicines

, Volume 62, Issue 2, pp 195-198

Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells

  • Haryoto SaroyobudionoAffiliated withNatural Products Research Group, Department of Chemistry, Bandung Institute of Technology
  • , Lia D. JuliawatyAffiliated withNatural Products Research Group, Department of Chemistry, Bandung Institute of Technology
  • , Yana M. SyahAffiliated withNatural Products Research Group, Department of Chemistry, Bandung Institute of Technology
  • , Sjamsul A. AchmadAffiliated withNatural Products Research Group, Department of Chemistry, Bandung Institute of Technology
  • , Euis H. HakimAffiliated withNatural Products Research Group, Department of Chemistry, Bandung Institute of Technology Email author 
  • , Jalifah LatipAffiliated withSchool of Chemistry and Food Technology, Faculty of Science and Technology, National University of Malaysia
  • , Ikram M. SaidAffiliated withSchool of Chemistry and Food Technology, Faculty of Science and Technology, National University of Malaysia

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Abstract

A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.

Keywords

Diptoindonesin F Oligostilbenoid Shorea gibbosa Dipterocarpaceae Cytotoxicity P-388 cells