Journal of Natural Medicines

, Volume 62, Issue 2, pp 195–198

Oligostilbenoids from Shorea gibbosa and their cytotoxic properties against P-388 cells

  • Haryoto Saroyobudiono
  • Lia D. Juliawaty
  • Yana M. Syah
  • Sjamsul A. Achmad
  • Euis H. Hakim
  • Jalifah Latip
  • Ikram M. Said
Note

DOI: 10.1007/s11418-007-0205-0

Cite this article as:
Saroyobudiono, H., Juliawaty, L.D., Syah, Y.M. et al. J Nat Med (2008) 62: 195. doi:10.1007/s11418-007-0205-0

Abstract

A new oligostilbenoid derivative, diptoindonesin F (1), along with five known oligostilbenoids, (−)-ampelopsin A (2), (−)-α-viniferin (3), ampelopsin E (4), (−)-vaticanol B (5), and (−)-hemsleyanol D (6), were isolated from the methanol extract of the tree bark of Shorea gibbosa. The structure of the new compound was determined based on the analysis of spectroscopic data, including UV, IR, NMR 1-D and 2-D, and mass spectra. Cytotoxic properties of the isolated oligostilbenoids were evaluated against murine leukemia P-388 cells with the result that compounds 2 and 4 showed the highest cytotoxicity.

Keywords

Diptoindonesin FOligostilbenoidShorea gibbosaDipterocarpaceaeCytotoxicityP-388 cells

Copyright information

© The Japanese Society of Pharmacognosy and Springer 2007

Authors and Affiliations

  • Haryoto Saroyobudiono
    • 1
  • Lia D. Juliawaty
    • 1
  • Yana M. Syah
    • 1
  • Sjamsul A. Achmad
    • 1
  • Euis H. Hakim
    • 1
  • Jalifah Latip
    • 2
  • Ikram M. Said
    • 2
  1. 1.Natural Products Research Group, Department of ChemistryBandung Institute of TechnologyBandungIndonesia
  2. 2.School of Chemistry and Food Technology, Faculty of Science and TechnologyNational University of MalaysiaBangiMalaysia