Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity
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Modern molecular biology has always been a great source of inspiration for computational science. Half a century ago, the challenge from understanding macromolecular dynamics has led the way for computations to be part of the tool set to study molecular biology. Twenty-five years ago, the demand from genome science has inspired an entire generation of computer scientists with an interest in discrete mathematics to join the field that is now called bioinformatics. In this paper, we shall lay out a new mathematical theory for dynamics of biochemical reaction systems in a small volume (i.e., mesoscopic) in terms of a stochastic, discrete-state continuous-time formulation, called the chemical master equation (CME). Similar to the wavefunction in quantum mechanics, the dynamically changing probability landscape associated with the state space provides a fundamental characterization of the biochemical reaction system. The stochastic trajectories of the dynamics are best known through the simulations using the Gillespie algorithm. In contrast to the Metropolis algorithm, this Monte Carlo sampling technique does not follow a process with detailed balance. We shall show several examples how CMEs are used to model cellular biochemical systems. We shall also illustrate the computational challenges involved: multiscale phenomena, the interplay between stochasticity and nonlinearity, and how macroscopic determinism arises from mesoscopic dynamics. We point out recent advances in computing solutions to the CME, including exact solution of the steady state landscape and stochastic differential equations that offer alternatives to the Gilespie algorithm. We argue that the CME is an ideal system from which one can learn to understand “complex behavior” and complexity theory, and from which important biological insight can be gained.
- Computational Cellular Dynamics Based on the Chemical Master Equation: A Challenge for Understanding Complexity
Journal of Computer Science and Technology
Volume 25, Issue 1 , pp 154-168
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- Print ISSN
- Online ISSN
- Springer US
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- biochemical networks
- cellular signaling
- master equation
- nonlinear reactions
- stochastic modeling
- Industry Sectors
- Author Affiliations
- 1. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A.
- 2. Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China
- 3. Department of Applied Mathematics, University of Washington, Seattle, WA, 98195, U.S.A.
- 4. Kavli Institute for Theoretical Physics China, Chinese Academy of Sciences, Beijing, 100190, China