, Volume 25, Issue 1, pp 124-130

Protein Interactome Analysis for Countering Pathogen Drug Resistance

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Abstract

Drug-resistant varieties of pathogens are now a recognized global threat. Insights into the routes for drug resistance in these pathogens are critical for developing more effective antibacterial drugs. A systems-level analysis of the genes, proteins, and interactions involved is an important step to gaining such insights. This paper discusses some of the computational challenges that must be surmounted to enable such an analysis; viz., unreliability of bacterial interactome maps, paucity of bacterial interactome maps, and identification of pathways to bacterial drug resistance.

This work was supported in part by Singapore National Research Foundation under Grant No. NRF-G-CRP-2997-04-082(d).