Journal of Biomedical Science

, Volume 13, Issue 2, pp 201–204

Mcl-1: a highly regulated cell death and survival controller


DOI: 10.1007/s11373-005-9064-4

Cite this article as:
Yang-Yen, HF. J Biomed Sci (2006) 13: 201. doi:10.1007/s11373-005-9064-4


Mcl-1 is one member of the Bcl-2 family that has a very short protein half-life. Since its identification in 1993, a great number of studies have implicated that Mcl-1 plays an important role in various cell survival pathways. However, not until recently did the molecular mechanism by which Mcl-1 antagonizes apoptosis have begun to be elucidated. Mcl-1 is rapidly degraded in response to cell death signals and is immediately re-induced by survival stimuli. These results indicate that Mcl-1 plays an apical role in many cell death and survival regulatory programs.


Mcl-1cell deathsurvival signals
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© National Science Council Taipei 2006

Authors and Affiliations

  1. 1.Institute of Molecular BiologyAcademia SinicaNankangTaiwan