Journal of Biomedical Science

, Volume 12, Issue 1, pp 13–29

Galectin-1 receptors in different cell types

  • María T. Elola
  • María E. Chiesa
  • Alejandra Fernández Alberti
  • José Mordoh
  • Nilda E. Fink
Article

DOI: 10.1007/s11373-004-8169-5

Cite this article as:
Elola, M.T., Chiesa, M.E., Alberti, A.F. et al. J Biomed Sci (2005) 12: 13. doi:10.1007/s11373-004-8169-5

Summary

Galectins are a family of animal lectins defined by two properties: shared amino acid sequences in their carbohydrate-recognizing domain, and β-galactoside affinity. A wide variety of biological phenomena are related to galectins, i.e., development, differentiation, morphogenesis, tumor metastasis, apoptosis, RNA splicing, and immunoregulatory function. In this review, we will focus on galectin-1 receptors, and some of the mechanisms by which this lectin affects different cell types. Several galectin-1 receptors are discussed such as CD45, CD7, CD43, CD2, CD3, CD4, CD107, CEA, actin, extracellular matrix proteins such as laminin and fibronectin, glycosaminoglycans, integrins, a β-lactosamine glycolipid, GM1 ganglioside, polypeptide HBGp82, glycoprotein 90 K/MAC-2BP, CA125 cancer antigen, and pre-B cell receptor.

Keywords

CD7 CD43 CD45 galectin-1 integrin laminin 

Abbreviations

CA125

cancer antigen CA125

CD

circular dichroism

CEA

carcinoembryonic antigen

CHO

Chinese hamster ovary

C2GnT

core 2 β-1,6-N-acetylglucosaminyltransferase

CRD

carbohydrate-recognizing domain

CR3

complement receptor 3

ECM

extracellular matrix

ER

endoplasmic reticulum

ERK

extracellular signal-regulated kinase

GAG

glycosaminoglycans

GM1

GM1 ganglioside

GNTV

β-1,6-N-acetylglucosaminyl-transferase V

HBGp82

human brain galectin-1-binding polypeptide of 82 kD

hsp

heat shock protein

90 K/MAC-2BP

glycoprotein of 90 kD or Mac-2-binding protein

LacNAc

N-acetyl-lactosamine

LAMP-1/2

lysosome-associated membrane proteins 1/2

LNnT

lacto-N-neotetraosyl ceramide

mAb

monoclonal antibody

MAPK

mitogen-activated protein kinase

MEK

mitogen-activated protein kinase kinase

MEKK

mitogen-activated protein kinase kinase kinase

MW

molecular weight

NMR

nuclear magnetic resonance

PL

poly-N-acetyl-lactosamine

pre-BCR

pre-B cell receptor

PTP

protein tyrosine phosphatase

RCA

Ricinus communis agglutinin

SLC

surrogate light chain

SMC

smooth muscle cells

SNA

Sambucus nigra agglutinin

ST6Gal I

sialyltransferase specific for SAα2,6Gal

TCR

T cell receptor

TDG

thiodigalactoside.

Copyright information

© National Science Council, Taipei 2005

Authors and Affiliations

  • María T. Elola
    • 1
  • María E. Chiesa
    • 2
  • Alejandra Fernández Alberti
    • 2
  • José Mordoh
    • 1
  • Nilda E. Fink
    • 2
  1. 1.Fundación Instituto LeloirInstituto de Investigaciones Bioquímicas de Buenos Aires, Patricias ArgentinasBuenos AiresArgentina
  2. 2.Departamento de Ciencias Biológicas, Facultad de Ciencias ExactasUniversidad Nacional de La PlataLa PlataArgentina