AGE

, 36:9639

Select aging biomarkers based on telomere length and chronological age to build a biological age equation

  • Wei-Guang Zhang
  • Shu-Ying Zhu
  • Xiao-Juan Bai
  • De-Long Zhao
  • Shi-Min Jiang
  • Juan Li
  • Zuo-Xiang Li
  • Bo Fu
  • Guang-Yan Cai
  • Xue-Feng Sun
  • Xiang-Mei Chen
Article

DOI: 10.1007/s11357-014-9639-y

Cite this article as:
Zhang, WG., Zhu, SY., Bai, XJ. et al. AGE (2014) 36: 9639. doi:10.1007/s11357-014-9639-y

Abstract

The purpose of this study is to build a biological age (BA) equation combining telomere length with chronological age (CA) and associated aging biomarkers. In total, 139 healthy volunteers were recruited from a Chinese Han cohort in Beijing. A genetic index, renal function indices, cardiovascular function indices, brain function indices, and oxidative stress and inflammation indices (C-reactive protein [CRP]) were measured and analyzed. A BA equation was proposed based on selected parameters, with terminal telomere restriction fragment (TRF) and CA as the two principal components. The selected aging markers included mitral annulus peak E anterior wall (MVEA), intima-media thickness (IMT), cystatin C (CYSC), D-dimer (DD), and digital symbol test (DST). The BA equation was: BA = −2.281TRF + 26.321CYSC + 0.025DD − 104.419MVEA + 34.863IMT − 0.265DST + 0.305CA + 26.346. To conclude, telomere length and CA as double benchmarks may be a new method to build a BA.

Keywords

Telomere length Biological age Chronological age Aging markers 

Copyright information

© American Aging Association 2014

Authors and Affiliations

  • Wei-Guang Zhang
    • 1
  • Shu-Ying Zhu
    • 2
  • Xiao-Juan Bai
    • 3
  • De-Long Zhao
    • 1
  • Shi-Min Jiang
    • 1
  • Juan Li
    • 4
  • Zuo-Xiang Li
    • 1
  • Bo Fu
    • 1
  • Guang-Yan Cai
    • 1
  • Xue-Feng Sun
    • 1
  • Xiang-Mei Chen
    • 1
  1. 1.Department of Nephrology, State Key Laboratory of Kidney Diseases (2011DAV00088), State Chronic Kidney Disease Clinical Research Center (2013BAI09B05)Chinese PLA General HospitalBeijingChina
  2. 2.Department of NephrologyThe Second Affiliated Hospital of Nanchang Medical UniversityNanchangChina
  3. 3.Departments of Gerontology and GeriatricsShengjing Hospital of China Medical UniversityShenyangChina
  4. 4.Department of CardiovascularChinese PLA General Hospital, State Key Laboratory of Kidney DiseasesBeijingChina

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