AGE

, Volume 36, Issue 2, pp 933–943

The rs1333049 polymorphism on locus 9p21.3 and extreme longevity in Spanish and Japanese cohorts

  • Tomàs Pinós
  • Noriyuki Fuku
  • Yolanda Cámara
  • Yasumichi Arai
  • Yukiko Abe
  • Gabriel Rodríguez-Romo
  • Nuria Garatachea
  • Alejandro Santos-Lozano
  • Elisabet Miro-Casas
  • Marisol Ruiz-Meana
  • Imanol Otaegui
  • Haruka Murakami
  • Motohiko Miyachi
  • David Garcia-Dorado
  • Kunihiko Hinohara
  • Antoni L. Andreu
  • Akinori Kimura
  • Nobuyoshi Hirose
  • Alejandro Lucia
Article

DOI: 10.1007/s11357-013-9593-0

Cite this article as:
Pinós, T., Fuku, N., Cámara, Y. et al. AGE (2014) 36: 933. doi:10.1007/s11357-013-9593-0

Abstract

The rs1333049 (G/C) polymorphism located on chromosome 9p21.3 is a candidate to influence extreme longevity owing to its association with age-related diseases, notably coronary artery disease (CAD). We compared allele/genotype distributions of rs1333049 in cases (centenarians) and controls (younger adults, without (healthy) or with CAD) in two independent cohorts: Spanish (centenarians: n = 152, 128 women, 100–111 years; healthy controls: n = 343, 212 women, age <50 years; CAD controls: n = 98, 32 women, age ≤65 years) and Japanese (centenarians: n = 742, 623 women, 100–115 years; healthy controls: n = 920, 511 women, < 60 years; CAD controls: n = 395, 45 women, age ≤65 years). The frequency of the “risk” C-allele tended to be lower in Spanish centenarians (47.0 %) than in their healthy (52.9 %, P = 0.088) or CAD controls (55.1 %, P = 0.078), and significant differences were found in genotype distributions (P = 0.034 and P = 0.045), with a higher frequency of the GG genotype in cases than in both healthy and CAD controls as well as a lower proportion of the CG genotype compared with healthy controls. In the Japanese cohort, the main finding was that the frequency of the C-allele did not differ between centenarians (46.4 %) and healthy controls (47.3 %, P = 0.602), but it was significantly lower in the former than in CAD controls (57.2 %, P < 0.001). Although more research is needed, the present and recent pioneer findings (Rejuvenation Res 13:23–26, 2010) suggest that the rs1333049 polymorphism could be among the genetic contributors to exceptional longevity in Southern European populations, albeit this association does not exist in the healthy (CAD-free) Japanese population.

Keywords

CentenariansGeneticsCoronary artery diseaseCDKN2ACDKN2B

Copyright information

© American Aging Association 2013

Authors and Affiliations

  • Tomàs Pinós
    • 1
    • 11
  • Noriyuki Fuku
    • 2
  • Yolanda Cámara
    • 1
    • 11
  • Yasumichi Arai
    • 3
  • Yukiko Abe
    • 3
  • Gabriel Rodríguez-Romo
    • 4
  • Nuria Garatachea
    • 5
  • Alejandro Santos-Lozano
    • 6
  • Elisabet Miro-Casas
    • 7
  • Marisol Ruiz-Meana
    • 7
  • Imanol Otaegui
    • 7
  • Haruka Murakami
    • 8
  • Motohiko Miyachi
    • 8
  • David Garcia-Dorado
    • 7
  • Kunihiko Hinohara
    • 9
  • Antoni L. Andreu
    • 1
    • 11
  • Akinori Kimura
    • 9
  • Nobuyoshi Hirose
    • 3
  • Alejandro Lucia
    • 10
  1. 1.Departament de Patología Mitocondrial i NeuromuscularInstitut de Recerca Hospital Universitari Vall d’HebronBarcelonaSpain
  2. 2.Department of Genomics for Longevity and HealthTokyo Metropolitan Institute of GerontologyTokyoJapan
  3. 3.Department of Internal MedicineKeio University School of MedicineTokyoJapan
  4. 4.INEFUniversidad PolitécnicaMadridSpain
  5. 5.Facultad de Ciencias de la Salud y del DeporteUniversidad de ZaragozaHuescaSpain
  6. 6.Departmento de Ciencias BiomédicasUniversidad de LeónLeónSpain
  7. 7.Departamento de CardiologíaHospital Universitari Vall d’HebronBarcelonaSpain
  8. 8.Department of Health Promotion and ExerciseNational Institute of Health and NutritionTokyoJapan
  9. 9.Department of Molecular Pathogenesis, Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan
  10. 10.Universidad Europea and Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12)MadridSpain
  11. 11.CIBER de Enfermedades Raras (CIBERER)BarcelonaSpain