AGE

, Volume 35, Issue 6, pp 2215–2227

Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques

  • A. A. Willette
  • C. L. Coe
  • A. C. Birdsill
  • B. B. Bendlin
  • R. J. Colman
  • A. L. Alexander
  • D. B. Allison
  • R. H. Weindruch
  • S. C. Johnson
Article

DOI: 10.1007/s11357-013-9518-y

Cite this article as:
Willette, A.A., Coe, C.L., Birdsill, A.C. et al. AGE (2013) 35: 2215. doi:10.1007/s11357-013-9518-y

Abstract

Higher systemic levels of the proinflammatory cytokine interleukin-6 (IL-6) were found to be associated with lower gray matter volume and tissue density in old rhesus macaques. This association between IL-6, and these brain indices were attenuated by long-term 30 % calorie restriction (CR). To extend these findings, the current analysis determined if a CR diet in 27 aged rhesus monkeys compared to 17 normally fed controls reduced circulating levels of another proinflammatory cytokine, interleukin-8 (IL-8), and raised levels of anti-inflammatory interleukin-10 (IL-10). Further, these cytokines were regressed onto imaged brain volume and microstructure using voxel-wise regression analyses. CR significantly lowered IL-8 and raised IL-10 levels. Across the two dietary conditions, higher IL-8 predicted smaller gray matter volumes in bilateral hippocampus. Higher IL-10 was associated with more white matter volume in visual areas and tracts. Consuming a CR diet reduced the association between systemic IL-8 and hippocampal volumes. Conversely, CR strengthened associations between IL-10 and microstructural tissue density in the prefrontal cortex and other areas, particularly in a region of dorsal prefrontal cortex, which concurred with our prior findings for IL-6. Consumption of a CR diet lowered proinflammatory and increased anti-inflammatory cytokine concentrations, which lessened the statistical association between systemic inflammation and the age-related alterations in important brain regions, including the hippocampus.

Keywords

Calorie restriction Interleukin-8 Interleukin-10 Hippocampus Prefrontal cortex Voxel 

Copyright information

© American Aging Association 2013

Authors and Affiliations

  • A. A. Willette
    • 1
    • 2
    • 3
  • C. L. Coe
    • 3
    • 4
  • A. C. Birdsill
    • 1
    • 3
  • B. B. Bendlin
    • 1
    • 3
  • R. J. Colman
    • 5
  • A. L. Alexander
    • 2
  • D. B. Allison
    • 6
  • R. H. Weindruch
    • 1
    • 3
  • S. C. Johnson
    • 1
    • 2
    • 3
    • 5
  1. 1.Geriatric Research Education and Clinical CenterWm. S. Middleton Memorial Veterans HospitalMadisonUSA
  2. 2.Waisman Laboratory for Brain Imaging and BehaviorUniversity of Wisconsin-MadisonMadisonUSA
  3. 3.Wisconsin Alzheimer’s Disease Research CenterUniversity of Wisconsin School of Medicine and Public HealthMadisonUSA
  4. 4.Harlow Primate Laboratory, Department of PsychologyUniversity of Wisconsin-MadisonMadisonUSA
  5. 5.Wisconsin National Primate Research CenterUniversity of Wisconsin-MadisonMadisonUSA
  6. 6.Office of EnergeticsUniversity of Alabama at BirminghamBirminghamUSA

Personalised recommendations