AGE

, Volume 35, Issue 5, pp 1949–1959

ACE I/D and ACTN3 R/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli

  • Ana Pereira
  • Aldo M. Costa
  • Mikel Izquierdo
  • António J. Silva
  • Estela Bastos
  • Mário C. Marques
Article

DOI: 10.1007/s11357-012-9461-3

Cite this article as:
Pereira, A., Costa, A.M., Izquierdo, M. et al. AGE (2013) 35: 1949. doi:10.1007/s11357-012-9461-3

Abstract

Genetic variation of the human ACE I/D and ACTN3 R577X polymorphisms subsequent to 12 weeks of high-speed power training on maximal strength (1RM) of the arm and leg muscles, muscle power performance (counter-movement jump), and functional capacity (sit-to-stand test) was examined in older Caucasian women [n = 139; mean age 65.5 (8.2) years; 67.0 (10.0) kg and 1.57 (0.06) m]. Chelex 100 was used for DNA extraction, and genotype was determined by PCR-RFLP methods. Muscular strength, power, and functional testing were conducted at baseline (T1) and after 12 weeks (T2) of high-speed power training. At baseline, the ACE I/D and ACTN3 R/X polymorphisms were not associated with muscle function or muscularity phenotypes in older Caucasian women. After the 12-week high-speed training program, subjects significantly increased their muscular and functional capacity performance (p < 0.05). For both polymorphisms, significant genotype-training interaction (p < 0.05) was found in all muscular performance indices, except for 1RM leg extension in the ACE I/D (p = 0.187). Analyses of the combined effects between genotypes showed significant differences in all parameters (p < 0.05) in response to high-speed power training between the power (ACTN3 RR + RX & ACE DD) versus “non-power” muscularity-oriented genotypes (ACTN3 XX & ACE II + ID)]. Our data suggest that the ACE and ACTN3 genotypes (single or combined) exert a significant influence in the muscle phenotypes of older Caucasian women in response to high-speed power training. Thus, the ACE I/D and ACTN3 R/X polymorphisms are likely factors in modulating exercise-related phenotypes in older women, particularly in response to a resistance training stimuli.

Keywords

Genotype Converting-enzyme genotype r577x genotypes Women Power 

Copyright information

© American Aging Association 2012

Authors and Affiliations

  • Ana Pereira
    • 1
    • 2
  • Aldo M. Costa
    • 2
    • 4
  • Mikel Izquierdo
    • 3
  • António J. Silva
    • 1
    • 2
  • Estela Bastos
    • 5
  • Mário C. Marques
    • 2
    • 4
  1. 1.Department of Sport SciencesUniversity of Trás-os-Montes and Alto DouroVila RealPortugal
  2. 2.Research Centre in SportsHealth and Human DevelopmentVila RealPortugal
  3. 3.Department of Health SciencesPublic University of NavarreTudelaSpain
  4. 4.Department of Sport SciencesUniversity of Beira InteriorCovilhãPortugal
  5. 5.Institute for Biotechnology and Bioengineering, Centre of Genomics and BiotechnologyUniversity of Trás-os-Montes and Alto DouroVila RealPortugal

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