AGE

, Volume 35, Issue 4, pp 1479–1493

Chronic psychosocial stress: does it modulate immunity to the influenza vaccine in Hong Kong Chinese elderly caregivers?

  • Samuel Yeung Shan Wong
  • Chun Kwok Wong
  • Frank Wan Kin Chan
  • Paul K. S. Chan
  • Karry Ngai
  • Stewart Mercer
  • Jean Woo
Article

DOI: 10.1007/s11357-012-9449-z

Cite this article as:
Wong, S.Y.S., Wong, C.K., Chan, F.W.K. et al. AGE (2013) 35: 1479. doi:10.1007/s11357-012-9449-z

Abstract

Previous studies evaluated the effects of psychosocial stress on influenza vaccine responses. However, there were methodological limitations. This study aims to determine whether chronic stress is associated with poorer influenza-specific immune responses to influenza vaccines in Hong Kong Chinese elderly people. This is a prospective study with a 12-week follow-up. Subjects were recruited from government general out-patient clinics, non-government organizations, and public housing estates in Hong Kong. Participants include 55 caregivers of spouses with chronic conditions that impaired their activities of daily living and 61 age- and sex-matched non-caregivers. A single-dose trivalent influenza vaccine was given to all subjects by intramuscular ingestion. Blood samples were collected before vaccination, at 6 weeks, and at 12 weeks after vaccination. Influenza vaccine strain-specific antibody titers were measured by the hemagglutination inhibition method. Lymphocyte subsets were analyzed for ratios and absolute counts, and cytokine concentration were measured by flow cytometry. Validated scales were used to assess psychological (depressive symptoms, perceived stress, and caregiver strain), social (multidimensional social support scale), and lifestyle factors (physical exercise, cigarette smoking, and alcohol consumption) at baseline prior to vaccination. Demographic and socioeconomic variables were also collected. Albumin levels were measured as an indicator for nutritional status in subjects. Caregivers had statistically significant (p < 0.05) lower cell-mediated immune responses to influenza vaccination at 12 weeks when compared with those of the controls. No differences in humoral immune response to vaccination were observed between caregivers and controls. Hong Kong Chinese elderly who experience chronic stress have a significantly lower cell-mediated immune response to influenza vaccination when compared with non-caregivers.

Keywords

Cohort studiesPsychological stressInfluenza vaccinesImmunityAsian continental ancestry group

Abbreviation

CSI

Caregiver Strain Index

Influenza B

B/Malaysia/2506/2004

GDS

Geriatric Depression Scale-Short Form

H1N1

A/New Caledonia/20/99

H3N2

A/Wisconsin/67/2005

HA

Hemagglutination

HAI

Hemagglutination inhibition

MSPSS

Multidimensional Scale of Perceived Social Support

PSS

Global Measure of Perceived Stress Scale

Copyright information

© American Aging Association 2012

Authors and Affiliations

  • Samuel Yeung Shan Wong
    • 1
    • 6
  • Chun Kwok Wong
    • 2
  • Frank Wan Kin Chan
    • 1
  • Paul K. S. Chan
    • 3
  • Karry Ngai
    • 3
  • Stewart Mercer
    • 4
  • Jean Woo
    • 5
  1. 1.The School of Public Health and Primary CareThe Chinese University of Hong KongShatinHong Kong
  2. 2.Department of Chemical PathologyThe Chinese University of Hong KongShatinHong Kong
  3. 3.Department of MicrobiologyThe Chinese University of Hong KongShatinHong Kong
  4. 4.General Practice and Primary Care, Institute of Health and WellbeingThe University of GlasgowGlasgowUK
  5. 5.Department of Medicine and TherapeuticsThe Chinese University of Hong KongShatinHong Kong
  6. 6.4/F, School of Public Health, Prince of Wales HospitalShatinHong Kong