AGE

, Volume 35, Issue 4, pp 1205–1217

Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8

Authors

  • Banu Bayram
    • Institute of Human Nutrition and Food ScienceChristian-Albrechts-University
    • Department of Food EngineeringIstanbul Technical University
  • Sibylle Nikolai
    • Institute of Human Nutrition and Food ScienceChristian-Albrechts-University
  • Patricia Huebbe
    • Institute of Human Nutrition and Food ScienceChristian-Albrechts-University
  • Beraat Ozcelik
    • Department of Food EngineeringIstanbul Technical University
  • Stefanie Grimm
    • Institute of Nutrition, Department of Nutritional ToxicologyFriedrich Schiller University
  • Tilman Grune
    • Institute of Nutrition, Department of Nutritional ToxicologyFriedrich Schiller University
  • Jan Frank
    • Institute of Biological Chemistry and NutritionUniversity of Hohenheim
    • Institute of Human Nutrition and Food ScienceChristian-Albrechts-University
Article

DOI: 10.1007/s11357-012-9448-0

Cite this article as:
Bayram, B., Nikolai, S., Huebbe, P. et al. AGE (2013) 35: 1205. doi:10.1007/s11357-012-9448-0

Abstract

In this study we compared biomarkers of oxidative stress, stress response, antioxidant defence and inflammation between mice (n = 10 per group, female, 7 months old) with an accelerated (SAMP8) and a normal ageing phenotype (SAMR1). As compared to SAMR1 mice, SAMP8 mice exhibited higher levels of lipid peroxides and protein carbonyls as well as a lower activity of the proteasomal subunit β-5. Furthermore, heme oxygenase-1 and paraoxonase-1 (PON-1) status was lower in SAMP8 mice indicating impaired stress response. Biomarkers of inflammation such as C-reactive protein and serum amyloid P were elevated in SAMP8 mice. Interestingly, impaired stress response and increased inflammation in SAMP8 mice were associated with elevated concentrations of ascorbic acid and α-tocopherol in the liver. An age-dependent increase in hepatic vitamin E and a decline in PON-1 gene expression were also observed in aged compared to young C57BL/6 mice.

Keywords

SAMP8Accelerated ageingStress responseProteasomal activityAscorbic acidTocopherol

Copyright information

© American Aging Association 2012