, Volume 28, Issue 2, pp 181-189

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice

  • Liou Y. SunAffiliated withDepartment of Pediatrics, Division of Endocrinology, University of North Carolina at Chapel Hill Email author 


Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.

Key words

growth hormone insulin-like growth factor I thymidine analogue 5’bromo-2-deoxyuridine subgranular zone dentate gyrus pituitary-specific transcription factor granule cell layer