AGE
, Volume 28, Issue 2, pp 181-189,
Open Access This content is freely available online to anyone, anywhere at any time.
Date: 13 Jun 2006

Hippocampal IGF-1 expression, neurogenesis and slowed aging: clues to longevity from mutant mice

Abstract

Recent studies point out the important role of IGF and insulin-related signaling pathways in the control of longevity of laboratory animals. The Ames dwarf mouse is a murine model of circulating GH and IGF-1 deficiency that exhibits dwarf phenotype characteristics and significantly extends lifespan. It is interesting to know that Ames dwarf mice do not experience an age-related decline in cognitive function when compared to their young counterparts. In this study, the most recent works on local GH and IGF-1 expression in the hippocampus of Ames mice are briefly reviewed.