, Volume 27, Issue 3, pp 225–239

Understanding and treating neurodegeneration: insights from the flies

Review article

DOI: 10.1007/s11357-005-2917-y

Cite this article as:
Lu, B. AGE (2005) 27: 225. doi:10.1007/s11357-005-2917-y


Drosophila has recently emerged as a model system for studying mechanisms of neurodegeneration. Genetic models for most of the major neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), polyglutamine diseases, and tauopathies, have been successfully established. Pharmacological models of some of these diseases have also been created. Genetic modifier screens using these models have uncovered previously implicated mechanisms and molecules as well as novel ones. Fly models have turned out to be excellent system for the in vivo testing of therapeutic potentials of candidate compounds. It is anticipated that further exploration of the fly models will not only provide novel insights into mechanisms of neurodegeneration but also lead to the development of rational treatment of those debilitating degenerative diseases.

Key words

Alzheimer's disease disease modeling Drosophila genetics Parkinson's disease polyglutamine disease tauopathy 

Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Department of Pathology, GRECC, VA Palo Alto Health Care SystemStanford University School of MedicinePalo AltoUSA

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