Mooradian, AD, Morley JE, and Korenman SG: Endocrinology in aging. Dis. Mon., 34:393–461, 1988.PubMed
Baumgartner, RN, Waters, DL, Gallagher, D, Morley, JE, and Garry, PJ: Predictors of skeletal muscle mass in elderly men and women. Mech. Ageing Dev., 107: 123–36, 1999.PubMed
Morley, JE, and Thomas, DR: Anorexia and aging: pathophysiology. Nutrition, 15:499–503, 1999.PubMed
Baumgartner, RN, Ross, RR, Waters, DL, Brooks, WM, Morley, JE, Montoya, GD, and Garry, PJ: Serum leptin in elderly people: associations with sex hormones, insulin, and adipose tissue volumes. Obes. Res., 7:141–9, 1999.PubMed
Friedman, EA: Advanced glycosylated end products and hyperglycemia in the pathogenesis of diabetic complications. Diabetes Care, 22:B65–71, 1999.PubMed
Morley, JE: Geriatrics, in Yearbook of Endocrinology, 1993, edited by Bagdade JD, St. Louis, Mosby, 1993, pp. 61–65.
Snowdon, DA, Kane, RL, Beeson, WL, Burke, GL, Sprafka, JM, Potter, J, Iso, H, Jacobs DR Jr, and Phillips, RL: Is early natural menopause a biologic marker of health and aging? Am. J. Public Health, 79:709–14, 1989.PubMed
Notelowitz, M: Menopause, in Endocrinology of Aging, edited by Morley, JE, VandenBerg, L, Totowa, NJ, Humana Press, 2000, pp. 161–181.
Sullivan, JM, and Fowlkes, LP: The clinical aspects of estrogen and the cardiovascular system. Obstet. Gynecol., 87: 36S–43S, 1996.PubMed
Prouder, AJ, Ahmed, Al, and Crook, D: Hormone replacement therapy and serum angiotensin-converting enzyme activity in postmenopausal women. Lancet, 346:89–90, 1995.
Newcomb, PA, and Storer, BE: Postmenopausal hormone use and risk of large bowel cancer. J. Natl. Cancer Inst., 87:1067–1071, 1995.PubMed
Flynn, BL: Pharmacologic management of Alzheimer disease, Part I: Hormonal and emerging investigational drug therapies. Ann. Pharmacother., 33:178–87, 1999.PubMed
Birge, SJ: Is there a role for estrogen replacement therapy in the prevention and treatment of dementia? J. Am. Geriatr. Soc., 44:865–70, 1996.PubMed
Flood, JF, and Morley, JE: Learning and memory in the SAMP8 mouse. Neurosci. Biobehav. Rev., 22: 1–20, 1998.PubMed
Henderson, BE, Paganini-Hill, A, and Ross, RK: Decreased mortality in users of estrogen replacement therapy. Arch. Intern. Med., 151:75–78, 1991.PubMed
Gray, A, Berlin, JA, McKinlay, JB, and Longcope C: An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. J. Clin. Epidemiol., 44:671–84, 1991.PubMed
Morley, JE, Kaiser, FE, Perry, HM 3rd, Patrick, P, Morley, PM, Stauber, PM, Vellas, B, Baumgartner, RN, and Garry PJ: Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. Metabolism, 46:410–13, 1997.PubMed
Korenman, SG, Morley, JE, Mooradian, AD, Davis, SS, Kaiser, FE, Silver, AJ, Viosca, SP, and Garza, D: Secondary hypogonadism in older men: its relation to impotence. J. Clin. Endocrinol. Metab. 71:963–9, 1990.PubMed
Morley, JE, and Perry, HM 3rd: Androgen deficiency in aging men. Med. Clin. North Am., 8: 1279–89, 1999.
Veldhuis, JD: Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamic-pituitary-gonadal axis: J. Androl., 20:1–17, 1999.PubMed
Pincus, SM, Veldhuis, JD, Mulligan, T, Iranmanesh, A, and Evans, WS: Effects of age on the irregularity of LH and FSH serum concentrations in women and men. Am. J. Physiol., 273:E989–95, 1997.PubMed
Pincus, SM, Mulligan, T, Iranmanesh, A, Gheorghiu, S, Godschalk, M, and Veldhuis, JD: Older males secrete luteinizing hormone and testosterone more irregularly, and jointly more asynchronously, than younger males. Proc. Natl. Acad. Sci. USA, 93:14100–5, 1996.
Haji, M, Kato, KI, Nawata, H, and Ibayashi, H: Age-related changes in the concentrations of cytosol receptors for sex steroid hormones in the hypothalamus and pituitary gland of the rat. Brain Res., 204:373–86, 1980.
Krithivas, K, Yurgalevitch, SM, Mohr, BA, Wilcox, CJ, Batter, SJ, Brown, M, Longcope, C, McKinlay, JB, and Kantoff, PW: Evidence that the CAG repeat in the androgen receptor gene is associated with the age-related decline in serum androgen levels in men. J. Endocrinol., 162:137–42, 1999.PubMed
Snyder, PJ, Peachey, H, Hannoush, P, Berlin, JA, Loh, L, Lenrow, DA, Holmes, JH, Dlewati, A, Santanna, J, Rosen, CJ, and Strom, BL: Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J. Clin. Endocrinol. Metab., 84:2647–53, 1999.PubMed
Urban RJ: Effects of testosterone and growth hormone on muscle function. J. Lab. Clin. Med., 134: 7–10, 1999.PubMed
Morley, JE, Perry, HM 3rd, Kaiser, FE, Kraenzle, D, Jensen, J, Houston, K, Mattammal, M, and Perry, HM Jr: Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J. Am. Geriatr. Soc., 41:149–52, 1993.PubMed
Sih, R, Morley, JE, Kaiser, FE, Perry, HM 3rd, Patrick, P, and Ross, C: Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. J. Clin. Endocrinol. Metab., 82:1661–7, 1997.PubMed
Urban, RJ, Bodenburg, YH, Gilkison, C, Foxworth, J, Coggan, AR, Wolfe, RR, and Ferrando, A: Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. Am. J. Physiol., 269: E820–6, 1995.PubMed
Snyder, PJ, Peachey, H, Hannoush, P, Berlin, JA, Loh, L, Holmes, JH, Dlewati, A, Staley, J, Santanna, J, Kapoor, SC, Attie, MF, Haddad, JG Jr, and Strom, BL. Effect of testosterone treatment on bone mineral density in men over 65 years of age. J. Clin. Endocrinol. Metab., 84:1966–72, 1999.PubMed
Janowsky, JS, Oviatt, SK, and Orwoll, ES: Testosterone influences spatial cognition in older men. Behav. Neurosci., 108:325–32, 1994.PubMed
Flood, JF, Farr, SA, Kaiser, FE, LaRegina, M, and Morley, JE: Age-related decrease of plasma testosterone in SAMP8 mice: replacement improves age-related impairment of learning and memory. Physiol. Behav., 57:669–73, 1995.PubMed
Barrett-Connor, EL: Testosterone and risk factors for cardiovascular disease in men. Diabete. Metab., 21:156–61, 1995.PubMed
Rosano, GM, Leonardo, F, Pagnotta, P, Pelliccia, F, Panina, G, Cerquetani, E, della Monica, PL, Bonfigli, B, Volpe, M, and Chierchia, SL: Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation, 99:1666–70, 1999.PubMed
Zhao, SP, Li, XP: The association of low plasma testosterone level with coronary artery disease in Chinese men. Int. J. Cardiol., 63:161–4, 1998.PubMed
Hajjar, RR, Kaiser, FE, and Morley, JE: Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospective analysis. J. Clin. Endocrinol. Metab., 82:3793–6, 1997.PubMed
Perry, HM 3rd, Horowitz, M, Morley, JE, Patrick, P, Vellas, B, Baumgartner, R, and Garry, PJ: Longitudinal changes in serum 25-hydroxyvitamin D in older people. Metabolism, 48:1028–32, 1999.PubMed
Jones, G, Strugnell, SA, and DeLuca, HF: Current understanding of the molecular actions of vitamin D. Physiol. Rev., 78:1193–231, 1998.PubMed
Chapuy, MC, Arlot, ME, Delmas, PD, Meunier, PJ: Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ, 308:1081–2, 1994.PubMed
Labrie, F, Belanger, A, Cusan, L, Gomez, JL, and Candas, B: Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J. Clin. Endocrinol. Metab., 82: 2396–402, 1997.PubMed
Flood, JF, Morley, JE, and Roberts, E: Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it. Proc. Natl. Acad. Sci. USA, 89:1567–1571, 1992.PubMed
Daynes, RA, and Aranco, BA: Prevention and reversal of some age-associated changes in immunologic responses by supplemental dehydroepiandrosterone sulfate therapy. Aging Immun. Infect. Dis., 3:135–154, 1992.
Arlt, W, Callies, F, van Vlijmen, JC, Koehler, I, Reincke, M, Bidlingmaier, M, Huebler, D, Oettel, M, Ernst, M, Schulte, HM, and Allolio, B: Dehydroepiandrosterone replacement in women with adrenal insuffiency. N. Engl. J. Med., 341:1013–1020, 1999.PubMed
Morales, AJ, Haubrich, RH, Hwang, JY, Asakura, H, and Yen, SS: The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin. Endocrinol. (Oxf)., 49:421–32, 1998.
Morales, AJ, Nolan, JJ, Nelson, JC, and Yen, SS. Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. J. Clin Endocrinol. Metab., 78:1360–7, 1994.PubMed
Barnhart, KT, Freeman, E, Grisso, JA, Rader, DJ, Sammel, M, Kapoor, S, Nestler, JE: The effect of deydroepiandrosterone supplementation to symptomatic perimenopausal women on serum endocrine profiles, lipid parameters, and health-related quality of life. J. Clin. Endocrinol. Metab., 84:3896–3902, 1999.PubMed
Morley, JE, Kaiser, F, Raum, WJ, Perry, M 3rd, Flood, JF, et al. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate. Proc. Natl. Acad. Sci. USA, 94:7537–7542, 1997.PubMed
McGavack, TH, Chevalley, J, and Weissberg, J: The use of D5 pregnenolone in various clinical disorders. J. Clin. Endocrinol. Metab., 11:559–577, 1951.PubMed
Flood, JF, Morley, JE, and Roberts, E: Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc. Natl. Acad. Sci. USA, 92:10806–10, 1995.
Steiger, A, Trachsel, I, Guldner, J, Hemmeter, U, Rothe, B, Rupprecht, R, Vedder, H, Holsboer, F: Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Res., 615:267–274, 1993.PubMed
Pincus, G, Hoagland, H, Wilson, CH, and Fay, NJ: Effects on industrial production of the administration of 5 pregnenolone to factory workers, II. Psychosom. Med. 7:342–346, 1945.
Sih, R, Morley, JE, Kaiser, FE, and Herning, M: Effects of pregnenolone on aging. J. Investig. Med. 45:348A, 1997.
Rudman, D: Growth hormone, body composition, and aging. J. Am. Geriatr. Soc., 33:800–7, 1985.PubMed
Lieberman, SA, and Hoffman, AR: The somatopause: should growth hormone deficiency in older people be treated? Clin. Geriatr. Med., 13:671–84, 1997.PubMed
Kaiser, FE, Silver, AJ, and Morley, JE: The effect of recombinant human growth hormone on malnourished older individuals. J. Am. Geriatr. Soc., 39:235–40, 1991.PubMed
Demling, R: Growth hormone therapy in critically ill patients. N. Engl. J. Med., 341:837–9, 1999.PubMed
Margulis, L: Genetic and evolutionary consequences of symbiosis. Exp. Parasitol., 39:277–349, 1976.PubMed
Margulis, L: Symbiosis and evolution. Sci. Am., 225:48–57, 1971.PubMed
Hayflick, L: Aging, longevity, and immortality in vitro. Exp. Gerontol., 27:363–8, 1992.PubMed
Vijg, J, and Wei, JY: Understanding the biology of aging: the key to prevention and therapy. J. Am. Geriatr. Soc. 43:426–34, 1995.PubMed
Ashok, BT, and Ali R: The aging paradox: free radical theory of aging. Exp. Gerontol., 34:293–303, 1999.PubMed
Veldhuis, JD: Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamic-pituitary-gonadal axis. J. Androl., 20:1–17, 1999.PubMed
Morley, JE: Anorexia of aging: physiologic and pathologic. Am. J. Clin. Nutr., 66:760–73, 1997.PubMed
Gosnell, BA, Levine, AS, and Morley, JE: The effects of aging on opioid modulation of feeding in rats. Life Sci., 32: 2793–9, 1983.PubMed
Kavaliers, M, Teskey, GC, and Hirst, M: The effects of aging on day-night rhythms of kappa opiatemediated feeding in the mouse. Psychopharmacology (Berl)., 87:286–91, 1985.
Jahnberg, T: Gastric adaptive relaxation. Effects of vagal activation and vagotomy. An experimental study in dogs and in man. Scand. J. Gastroenterol. Suppl., 46:1–32, 1977.PubMed
Desai, KM, Sessa, WC, and Vane, JR: Involvement of nitric oxide in the reflex relaxation of the stomach to accomodate food or fluid. Nature, 351:477–9, 1991.PubMed
Jones, KL, Doran, SM, Hveem, K, Bartholomeusz, FD, Morley, JE, Sun, WM, Chatterton, BE, and Horowitz, M: Relation between postprandial satiation and antral area in normal subjects. Am. J. Clin. Nutr. 66:127–32, 1997.PubMed
Cook, CG, Andrews, JM, Jones, KL, Wittert, GA, Chapman, IM, Morley, JE, and Horowitz, M: Effects of small intestinal nutrient infusion on appetite and pyloric motility are modified by age. Am. J. Physiol., 273: R755–61, 1997.PubMed
Silver, AJ, Flood, JF, Morley, JE: Effect of gastrointestinal peptides on ingestion in old and young mice. Peptides, 9:221–5, 1988.PubMed
Miyasaka, K, Kanai, S, Ohta, M, and Funakoshi, A: Aging impairs release of central and peripheral cholecystokinin (CCK) in male but not in female rats. J. Gerontol. A Biol. Sci. Med. Sci., 52:M14–8, 1997.PubMed
James, WPT and Ralph, A. New understanding in obesity research. Proc. Nutr. Soc 58:385–393, 1999.PubMed
Perry, HM 3rd, Morley, JE, Horowitz, M, Kaiser, FE, Miller, DK, and Wittert, G: Body composition and age in African-American and Caucasian women: relationship to plasma leptin levels. Metabolism, 46:1399–405, 1997.PubMed
Morley, JE, Perry, HM 3rd, Baumgartner, RP, and Garry, PJ: Leptin, adipose tissue and aging—is there a role for testosterone? J. Gerontol. Ser. A Biol. Sci. Med. Sci., 54:B108–9, 1999.
Larsson, H, Elmstahl, S, Berglund, G, Ahren, B: Evidence for leptin regulation of food intake in humans. J. Clin. Endocrinol. Metab., 83:4382–5, 1998.PubMed
Mott, JW, Wang, J, Thornton, JC, Allison, DB, Heymsfield, SB, and Pierson, RN, Jr: Relation between body fat and age in 4 ethnic groups. Am. J. Clin. Nutr., 69:1007–13, 1999.PubMed
Silver, AJ, Guillen, CP, Kahl, MJ, and Morley, JE: Effect of aging on body fat. J. Am. Geriatr. Soc., 41:211–3, 1993.PubMed
Wilson, MMG, Vaswani, S, Liu, D, Morley, JE, and Miller, DK. Prevalence and causes of undernutrition in medical outpatients. Am. J. Med., 104:56–63, 1998.PubMed
Baez-Franceschi, D, and Morley, JE: Physiopathology of the catabolism associated with malnutrition in the elderly. Z. Gerontol. Geriatr. 32:12–19, 1999.
Morley, JE: The elderly Type 2 diabetic patient: special considerations. Diabet. Med., 15:S41–6, 1998.PubMed
Sensi, M, Pricci F, Andreani, D, and DiMario U: Advanced nonenzymatic glycation endproducts (AGE): their relevance to aging and the pathogenesis of late diabetic complications. Diabetes Res. 16:1–9, 1991.PubMed
Arner, P, Pollare, T, and Lithell, H: Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia, 34:483–487, 1991.PubMed
Meneilly, GS, Elahi, D, Minaker, KL, Sclater, AL, Rowe, JW: Impairment of noninsulin-mediated glucose disposal in the elderly. J. Clin. Endocrinol. Metab., 63:566–571, 1989.
Meneilly, GS, Elliott, T, Tessier, D, Hards, L, Tildesley, H: NIDDM in the elderly. Diabetes Care, 19:1320–5, 1996.PubMed
Miller, DK, Lui, LY, Perry, HM 3rd, Kaiser, FE, and Morley, JE: Reported and measured physical functioning in older inner-city diabetic African Americans. J. Gerontol. Ser. A Biol. Sci. Med. Sci., 54:M230–6, 1999.
Meneilly, GS: Pathophysiology of type 2 diabetes in the elderly. Clin. Geriatr. Med., 15:239–253, 1999.PubMed
Ferrannini, E, Vichi, S., Beck-Nielsen, H, Laakso, M, Paolisso G, Smith, U. Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes, 45:947–53, 1996.PubMed
Daniel, PM, Love, ER, and Pratt, OE: The effect of age upon the influx of glucose into the brain. J. Physiol. (London), 274:141–148, 1978.
De Vivo, DC, Trifiletti, RR, Jacobson, RI, Ronen GM, Behmand, RA, and Harik SI: Defective glucose transport across the blood-brain barrier as a cause of persistent hypoglycorrhacia, seizures, and developmental delay. N. Engl. J. Med., 325:703–709, 1991.PubMed
Forbes, A, Elliott, T, Tildesley, H, Finegood, D, Meneilly, GS: Alterations in non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes 47:1915–9, 1998.PubMed
Meneilly, GS, Milberg, WP, and Tuokko, H: Differential effects of human and animal insulin on the responses to hypoglycemia in elderly patients with NIDDM. Diabetes, 44:272–277, 1995.PubMed
Banks, WA, Jaspan, JB, and Kastin, AJ: Selective, physiological transport of insulin across the blood-brain barrier: Novel demonstration by species-specific radioimmunoassays. Peptides, 18:1257–1262, 1997.PubMed
Das, UN: GLUT-4, tumor necrosis factor, essential fatty acids and daf-genes and their role in insulin resistance and non-insulin dependent diabetes mellitus. Prostaglandins Leukot. Essent. Fatty Acids, 50:13–20, 1999.
Hekimi, S, Lakowski, B, Barnes, TM, Ewbank, JJ: Molecular genetics of life span in C. elegans: how much does it teach us? Trends Genet., 14:14–20, 1998.PubMed
Kimura, KD, Tissenbaum, HA, Liu, Y, and Ruvkun, G: daf-2, an Insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
. Science, 277:942–946, 1997.PubMed
Kops, GJ, de Ruiter, ND, De Vries-Smits, AM, Powell, DR, Bos JL and Th. Burgering, BM: Direct control of the forkhead transcription factor AFX by protein kinase B. Nature, 398:630–634, 1999.PubMed
Nakae, J, Park, B-C, and Accili, D: Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on Serine 253 through a Wortmannin-sensitive pathway. J. Biol. Chem., 274:15982–15985, 1999.
Vanfleteren, JR, and De Vreese, A: The gerontogenes age-1 and daf-2 determine metabolic rate potential in aging Caenorhabditis elegans. FASEB J., 9:1355–61, 1995.PubMed
Lakowski, B, and Hekimi, S: The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA, 95:13091–6, 1998.
Paolisso, G, Tagliamonte, MR, Rizzo, MR, and Giugliano, D: Advancing age and insulin resistance: new factors about an ancient history. Eur. J. Clin. Invest., 29:758–769, 1999.PubMed
Taub, J, Lau, JF, Ma, C, Hahn, JH, Hoque, F, Rothblatt, J and Chalfie, M: A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C
mutants. Nature, 399:162–166, 1999.PubMed
Honda, Y, and Honda, S: The daf-2
gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
. FASEB J., 13:1385–1393, 1999.PubMed
Yasuda, K, Adachi, H, Fujiwara, Y, and Ishii, N. Protein carbonyl accumulation in aging dauer formation-defective (daf) mutants of Caenorhabditis elegans. J. Gerontol., 54:B47–51, 1999.
Banks, WA, Kastin, AJ, Huang, W, Jaspan, JB, and Maness, LM: Leptin enters the brain by a saturable system independent of insulin. Peptides, 17:305–311, 1996.PubMed
Campfield, LA, Smith FJ, Guisez, Y, Devos, R, and Burn, P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science, 269:546–549, 1995.PubMed
Halaas, JL, Gajiwala, KS, Maffei, M, Cohen, SL, Chait, BT, Rabinowitz, D, Lallone, RL, Burley, SK, and Friedman, JM: Weight-reducing effects of the plasma protein encoded by the obese
gene. Science, 269: 543–546, 1995.PubMed
Pelleymounter, MA, Cullen, MJ, Baker, MB, Hecht, R, Winters, D, Boone, T, and Collins, F: Effects of the obese
gene product on body weight regulation in ob/ob
mice. Science, 269:540–543, 1995.PubMed
Zhang, Y, Proenca, R, Maffel, M, Barone, M, Leopold, L, and Friedman, JM: Positional cloning of the mouse obese
gene and its human homologue. Nature, 372:425–432, 1994.PubMed
Banks, WA, DiPalma, CR, and Farrell CL: Impaired transport of leptin across the blood-brain barrier in obesity. Peptides, 20:1341–5, 1999.PubMed
Corica, F, Allegra, A, Corsonello, A, Buemi, M, Calapai, G, Ruello, A, Nicita Mauro, V, and Ceruso, D: Relationship between plasma leptin levels and the tumor necrosis factor-alpha system in obese subjects. Int. J. Obes. Relat. Metab. Disord., 23:355–60, 1999.PubMed
Paolisso, G, Rizzo, MR, Mazziotti, G, Tagliamonte, MR, Gambardella, A, Rotondi, M, Carella, C, Giugliano, D, Varricchio, M, and D’Onofrio, F: Advancing age and insulin resistance: role of plasma tumor necrosis factor-α. Am. J. Physiol., 275:E294–299, 1998.PubMed
Nilsson, J, Jovinge, S, Niemann, A, Reneland, R, and Lithell, H: Relation between plasma tumor necrosis factor-alpha and insulin sensitivity in elderly men with non-insulin-dependent diabetes mellitus. Arterioscler. Thromb. Vasc. Biol., 18:1199–202, 1998.PubMed
Zinman, B, Hanley, AJ, Harris, SB, Kwan, J, and Fantus, IG: Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus. J. Clin. Endocrinol. Metab., 84:272–8, 1999.PubMed
Hube, F, Birgel, M, Lee, YM, and Hauner, H: Expression pattern of tumour necrosis factor receptors in subcutaneous and omental human adipose tissue: role of obesity and non-insulin-dependent diabetes mellitus. Eur. J. Clin. Invest. 29:672–8, 1999.PubMed
Lang, CH, Dobrescu, C, and Bagby, GJ: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology, 130:43–52, 1992.PubMed
Hotamisligil, GS: Mechanisms of TNF-alpha-induced insulin resistance. Exp. Clin. Endocrinol. Diabetes, 107:111–2, 1999.
Uysal, KT, Wiesbrock, SM, Marino, MW, and Hotamisligil, GS: Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature, 389:610–4, 1997.PubMed
Cheung, AT, Ree, D, Kolls, JK, Fuselier, J, Coy, DH, and Bryer-Ash, M: An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha. Endocrinology, 139:4928–35, 1998.PubMed
Miles, PD, Romeo, OM, Higo, K, Cohen, A, Rafaat, K, and Olefskyk, JM: TNF-alpha-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes, 46:1678–83, 1997.PubMed
Hofmann, C, Lorenz, K, Braithwaite, SS, Colca, JR, Palazuk, BJ, Hotamisligil, GS, and Spiegelman, BM: Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology, 134:264–70, 1994.PubMed
Kwon, G, Xu, G, Marshall, CA, and McDaniel, ML: Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression. J. Biol. Chem., 274:18702–8, 1999.
Winkler, G, Lakatos, P, Salamon, F, Nagy, Z., Speer, G, Kovacs, M, Harmos, G, Dworak, O., and Cseh, K. Elevated serum TNF-alpha level as a link between endothelial dysfunction and insulin resistance in normotensive obese patients. Diabet. Med., 16:207–11, 1999.PubMed
McKendrick, JD, Salas, E., Dube, GP, Murat, J., Russell, JC, and Radomski, MW: Inhibition of nitric oxide generation unmasks vascular dysfunction in insulin-resistant, obese JCR:LA-cp rats. Brit. J. Pharmacol., 124: 361–9, 1998.
Estrada, C, Gomez, C, Martin, C, Moncada, S, and Gonzalez C: Nitric oxide mediates tumor necrosis factor-α cytotoxicity in endothelial cells. Biochem. Biophys. Res. Commun., 186:475–482, 1992.PubMed
Polte, T, and Schroder, H: Cyclic AMP mediated endothelial protection by nitric oxide. Biochem. Biophys. Res. Commun., 251:460–465, 1998.PubMed
Baron, AD: The coupling of glucose metabolism and perfusion in human skeletal muscle. The potential role of endothelium-derived nitric oxide. Diabetes, 45:S105–9, 1996.PubMed