Sleep and Breathing

, Volume 17, Issue 4, pp 1187–1192

Low serum copeptin levels in patients with obstructive sleep apnea

  • Serkan Ozben
  • Tolga Sinan Guvenc
  • Nergiz Huseyinoglu
  • Hilal Safak Sanivar
  • Ferhat Hanikoglu
  • Aysegul Cort
  • Tomris Ozben
Original Article

DOI: 10.1007/s11325-013-0822-7

Cite this article as:
Ozben, S., Guvenc, T.S., Huseyinoglu, N. et al. Sleep Breath (2013) 17: 1187. doi:10.1007/s11325-013-0822-7

Abstract

Purpose

Copeptin, the C-terminal fragment of antidiuretic hormone (ADH), is a new biomarker that has been found to be elevated in several cardiovascular disorders and is related with prognosis. Patients with obstructive sleep apnea demonstrate a tendency to develop coronary and cerebral atherosclerotic disease. Our aim was to investigate copeptin levels in untreated new diagnosed obstructive sleep apnea patients without manifest cardiovascular disorders in order to determine whether copeptin could be used as a biomarker in this group.

Methods

A total of 60 patients with obstructive sleep apnea, diagnosed with polysomnography, and 23 healthy volunteers were enrolled into this study. Blood samples were collected after overnight fasting, and copeptin level was measured with an enzyme immunoassay method.

Results

Patients with obstructive sleep apnea had a higher incidence of hypertension and body mass index but lower serum copeptin level (0.48 ± 0.24. vs. 0.64 ± 0.28 ng/ml, p = 0.007) compared with the healthy controls. There was no significant difference regarding to serum copeptin levels between the moderate (n = 13) and severe (n = 47) obstructive sleep apnea patients (0.42 ± 0.18 vs. 0.49 ± 0.26 ng/ml, p = 0.409).

Conclusions

Rather than reflecting a reduced risk for cardiovascular disorders, we consider that reduced copeptin level is related with disturbed ADH secretion in obstructive sleep apnea patients. Therefore, it would not be advisable to measure copeptin levels in obstructive sleep apnea patients to determine cardiovascular risk, while this marker could be valuable to demonstrate impairment in ADH regulation in this patient group.

Keywords

Obstructive sleep apnea Copeptin Antidiuretic hormone Cardiovascular diseases 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Serkan Ozben
    • 1
  • Tolga Sinan Guvenc
    • 2
  • Nergiz Huseyinoglu
    • 1
  • Hilal Safak Sanivar
    • 1
  • Ferhat Hanikoglu
    • 3
  • Aysegul Cort
    • 3
  • Tomris Ozben
    • 3
  1. 1.Department of Neurology, Medical FacultyKafkas UniversityKarsTurkey
  2. 2.Department of Cardiology, Medical FacultyKafkas UniversityKarsTurkey
  3. 3.Department of Biochemistry, Medical FacultyAkdeniz UniversityAntalyaTurkey

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