Sleep and Breathing

, Volume 17, Issue 3, pp 905–910

Oxidative stress, cancer, and sleep deprivation: is there a logical link in this association?

  • Juliana Noguti
  • Monica Levy Andersen
  • Chiara Cirelli
  • Daniel Araki Ribeiro

DOI: 10.1007/s11325-012-0797-9

Cite this article as:
Noguti, J., Andersen, M.L., Cirelli, C. et al. Sleep Breath (2013) 17: 905. doi:10.1007/s11325-012-0797-9



Sleep disorders are associated with various human pathologies and interfere with biological processes essential for health and quality of life. On the other hand, cancer is one of the most common diseases worldwide with an average of 1,500 deaths per day in the USA. Is there a factor common to both sleep disorders and cancer that serves to link these conditions?


It is a normal process for cellular metabolism to produce reactive oxidant series (ROS). However, when the production of ROS overcomes the antioxidant capacity of the cell to eliminate these products, the resulting state is called oxidative stress. Oxidative DNA damage may participate in ROS-induced carcinogenesis. Moreover, ROS are also produced in the sleep deprivation process. The aim of this article is to review pathways and mechanisms that may point to oxidative stress as a link between sleep deprivation and cancer.


Sleep deprivation Cancer Oxidative stress 

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Juliana Noguti
    • 1
  • Monica Levy Andersen
    • 2
  • Chiara Cirelli
    • 3
  • Daniel Araki Ribeiro
    • 1
    • 4
  1. 1.Department of PathologyFederal University of São Paulo–UNIFESPSao PauloBrazil
  2. 2.Department of PsychobiologyFederal University of São Paulo–UNIFESPSao PauloBrazil
  3. 3.Department of PsychiatryUniversity of WisconsinMadisonUSA
  4. 4.Department of BiosciencesFederal University of São Paulo–UNIFESPSantosBrazil

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