Sleep and Breathing

, Volume 18, Issue 1, pp 13–18

Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism

  • Ajibola Monsur Adedayo
  • Oladipupo Olafiranye
  • David Smith
  • Alethea Hill
  • Ferdinand Zizi
  • Clinton Brown
  • Girardin Jean-Louis
Review

DOI: 10.1007/s11325-012-0760-9

Cite this article as:
Adedayo, A.M., Olafiranye, O., Smith, D. et al. Sleep Breath (2014) 18: 13. doi:10.1007/s11325-012-0760-9

Abstract

Introduction

Over the past half century, evidence has been accumulating on the emergence of obstructive sleep apnea (OSA), the most prevalent sleep-disordered breathing, as a major risk factor for cardiovascular disease. A significant body of research has been focused on elucidating the complex interplay between OSA and cardiovascular risk factors, including dyslipidemia, obesity, hypertension, and diabetes mellitus that portend increased morbidity and mortality in susceptible individuals.

Conclusion

Although a clear causal relationship of OSA and dyslipidemia is yet to be demonstrated, there is increasing evidence that chronic intermittent hypoxia, a major component of OSA, is independently associated and possibly the root cause of the dyslipidemia via the generation of stearoyl-coenzyme A desaturase-1 and reactive oxygen species, peroxidation of lipids, and sympathetic system dysfunction. The aim of this review is to highlight the relationship between OSA and dyslipidemia in the development of atherosclerosis and present the pathophysiologic mechanisms linking its association to clinical disease. Issues relating to epidemiology, confounding factors, significant gaps in research and future directions are also discussed.

Keywords

Obstructive sleep apnea Chronic intermittent hypoxia (CIH) Dyslipidemia Cardiovascular risks 

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Ajibola Monsur Adedayo
    • 1
  • Oladipupo Olafiranye
    • 1
  • David Smith
    • 3
  • Alethea Hill
    • 4
  • Ferdinand Zizi
    • 1
  • Clinton Brown
    • 1
  • Girardin Jean-Louis
    • 1
    • 2
  1. 1.Department of Medicine, SUNY Downstate Medical Center (Box 1199)Brooklyn Health Disparities CenterBrooklynUSA
  2. 2.Department of Medicine, SUNY Downstate Medical CenterSleep Disorders CenterBrooklynUSA
  3. 3.Primary Care Internal MedicineYale University School of MedicineNew HavenUSA
  4. 4.Adult Health Nursing DepartmentUniversity of South AlabamaMobileUSA

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