Sleep and Breathing

, Volume 15, Issue 3, pp 471–478

Risk of sleep-disordered breathing in Parkinson's disease

Authors

  • Wattanachai Chotinaiwattarakul
    • Sleep Disorders Center and Department of NeurologyUniversity of Michigan
  • Praveen Dayalu
    • Movement Disorders Clinic and Department of NeurologyUniversity of Michigan
  • Ronald D. Chervin
    • Sleep Disorders Center and Department of NeurologyUniversity of Michigan
    • Movement Disorders Clinic and Department of NeurologyUniversity of Michigan
    • Geriatrics Research, Education, and Clinical CenterVAAAHS
Original Article

DOI: 10.1007/s11325-010-0362-3

Cite this article as:
Chotinaiwattarakul, W., Dayalu, P., Chervin, R.D. et al. Sleep Breath (2011) 15: 471. doi:10.1007/s11325-010-0362-3
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Abstract

Objective

The objective of this study is to assess the risk of sleep-disordered breathing (SDB) in patients with Parkinson's disease (PD) in a cross-sectional survey of PD subjects and controls in a university-based movement disorders clinic.

Methods

One hundred thirty-four consecutive PD subjects and 94 control subjects without prior diagnosis of SDB were assessed. Participants were assessed with clinical history, Unified Parkinson's Disease Rating Scale, Geriatric Depression Scale, Berlin Questionnaire to classify SDB risk, Epworth Sleepiness Scale, Parkinson's Disease Sleep Scale, and SF-36 to examine quality of life. The presence of risk for SDB was assessed by the Berlin Questionnaire.

Results

High risk for SDB was apparent in 66 (49.3%) of the PD patients and 32 (34.8%) of the controls. After adjustment for age, gender, and body mass index (BMI), PD subjects in comparison to controls showed higher risk for SBD (odds ratio = 2.81; 95% confidence interval, 1.36–5.82). Quality of life (physical component score) was significantly diminished in PD patients at high risk for SDB. PD severity did not correlate well with SDB risk. PD patients at high risk for SDB had higher BMIs and Epworth scores.

Conclusions

PD patients have features suggesting increased risk for SDB. This frequently undiagnosed sleep disorder may have a substantial impact on quality of life of PD patients.

Keywords

Sleep-disordered breathingObstructive sleep apneaParkinson's diseaseBerlin questionnaireSleepinessDepressionQuality of life

Copyright information

© Springer-Verlag 2010