Molecular Imaging and Biology

, Volume 14, Issue 3, pp 286–292

Fast-Specific Tomography Imaging via Cerenkov Emission

  • Jianghong Zhong
  • Chenghu Qin
  • Xin Yang
  • Zhe Chen
  • Xiang Yang
  • Jie Tian
Research Article

DOI: 10.1007/s11307-011-0510-6

Cite this article as:
Zhong, J., Qin, C., Yang, X. et al. Mol Imaging Biol (2012) 14: 286. doi:10.1007/s11307-011-0510-6

Abstract

Purpose

Development of more tumor-specific radiopharmaceuticals is not enough; to understand the disease, we must study data modeling. Although fluoro-18-deoxyglucose positron emission tomography can map a multi-peak distribution of trace radioisotopes, optical tomography should also be able to redirect the distribution.

Procedures

Multi-view image acquisition of small animals injected with 2-deoxy-2-[18F]fluoro-d-glucose began with X-ray computed tomography scanning and Cerenkov luminescence imaging. After fusion processing, utilization of the geometric row scaling and L1/2 regularization operator effectively generates in vivo Cerenkov luminescence tomography images with the SP3 forward model.

Results

The identification is confirmed by the comparison between tumor-specific tomography from Cerenkov emission and the radioactivity measured in vitro.

Conclusion

The proposed technique can quickly localize the mobility of radionuclides and uptake by organs, which provides an imaging methodology in oncology.

Key words

Cerenkov radiationTomography18FDGImaging radiopharmaceuticals

Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2011

Authors and Affiliations

  • Jianghong Zhong
    • 1
  • Chenghu Qin
    • 1
  • Xin Yang
    • 1
  • Zhe Chen
    • 1
  • Xiang Yang
    • 1
  • Jie Tian
    • 1
  1. 1.Intelligent Medical Research Center, Institute of AutomationChinese Academy of SciencesBeijingChina