Molecular Imaging and Biology

, Volume 13, Issue 5, pp 1029–1035

Determinants of Physiologic 18F-FDG Uptake in Brown Adipose Tissue in Sequential PET/CT Examinations

  • Leonardo Pace
  • Emanuele Nicolai
  • Domenico D’Amico
  • Francesco Ibello
  • Anna Maria Della Morte
  • Barbara Salvatore
  • Laura Micol Pizzuti
  • Marco Salvatore
  • Andrea Soricelli
Research Article

DOI: 10.1007/s11307-010-0431-9

Cite this article as:
Pace, L., Nicolai, E., D’Amico, D. et al. Mol Imaging Biol (2011) 13: 1029. doi:10.1007/s11307-010-0431-9

Abstract

Purpose

The aim of this study was to assess independent predictors of 2-deoxy-2-[18F]fluoro-d-glucose (18F-FDG) uptake in brown adipose tissue (BAT) in patients undergoing repeated positron emission tomography (PET)/computed tomography (CT) scans.

Procedures

Eight hundred forty-eight (mean age 50.9 ± 16 years) patients in whom PET/CT scan was repeated (mean interval 5 ± 1.5 months) constituted the study group. 18F-FDG uptake in characteristic areas of BAT, with CT density of adipose tissue, greater than background soft-tissue activity was considered as evidence of BAT uptake. Both distribution and maximum standardized uptake values (SUVmax) were registered. Clinical and anamnestic data were collected for each patient.

Results

18F-FDG uptake in BAT was present in 8.6% patients at first scan. Independent predictors of presence of uptake were age (younger), gender (female), body mass index (lower), and maximum outdoor temperature (lower). Age was the only independent predictor of BAT 18F-FDG uptake distribution, while SUVmax was related to both age and outdoor temperature. Independent determinants of persistence of BAT 18F-FDG uptake at second PET/CT were outdoor temperature at time of second scan and extension of metabolically active BAT at first scan.

Conclusions

Age, body mass index, and outdoor temperature are significant determinants of BAT evidence at 18F-FDG PET/CT. Moreover, extension of BAT and outdoor temperature are the strongest determinants of persistence of BAT evidence on 18F-FDG PET/CT in repeated scan.

Key words

Brown adipose tissue18F-FDGPET/CT

Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2010

Authors and Affiliations

  • Leonardo Pace
    • 1
    • 2
  • Emanuele Nicolai
    • 3
  • Domenico D’Amico
    • 3
  • Francesco Ibello
    • 3
  • Anna Maria Della Morte
    • 3
  • Barbara Salvatore
    • 3
  • Laura Micol Pizzuti
    • 1
  • Marco Salvatore
    • 1
  • Andrea Soricelli
    • 3
    • 4
  1. 1.Dipartimento di Scienze Biomorfologiche e Funzionali, Facoltà di Medicina e ChirurgiaUniversità degli Studi di Napoli Federico IINapoliItaly
  2. 2.Instituto di Biostrutture e Bioimmagini, C.N.R.NaplesItaly
  3. 3.Fondazione SDN-IRCCSNaplesItaly
  4. 4.Università degli Studi di Napoli ParthenopeNaplesItaly