Molecular Imaging and Biology

, Volume 13, Issue 4, pp 599–612

Preclinical Lymphatic Imaging

Review Article

DOI: 10.1007/s11307-010-0421-y

Cite this article as:
Zhang, F., Niu, G., Lu, G. et al. Mol Imaging Biol (2011) 13: 599. doi:10.1007/s11307-010-0421-y


Noninvasive in vivo imaging of lymphatic vessels and lymphatic nodes is expected to fulfill the purpose of analyzing lymphatic vessels and their function, understanding molecular mechanisms of lymphangiogenesis and lymphatic spread of tumors, and utilizing lymphatic molecular markers as a prognostic or diagnostic indicator. In this review, we provide a comprehensive summary of in vivo imaging modalities for detecting lymphatic vessels, lymphatic drainage, and lymphatic nodes, which include conventional lymphatic imaging techniques such as dyes and radionuclide scintigraphy as well as novel techniques for lymphatic imaging such as optical imaging, computed tomography, magnetic resonance imaging, ultrasound, positron emission tomography using lymphatic biomarkers, photoacoustic imaging, and combinations of multiple modalities. The field of lymphatic imaging is ever evolving, and technological advances, combined with the development of new contrast agents, continue to improve the research of lymphatic vascular system in health and disease states as well as to improve the accuracy of diagnosis in the relevant diseases.

Key words

Lymphatic imaging Lymphangiography Contrast agent Molecular imaging 

Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2010

Authors and Affiliations

  1. 1.Laboratory of Molecular Imaging and Nanomedicine (LOMIN)National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)BethesdaUSA
  2. 2.Department of Radiology, Nanjing Jinling HospitalClinical School of Medical College of Nanjing UniversityNanjingChina
  3. 3.Imaging Sciences Training Program, Radiology and Imaging SciencesClinical Center and National Institute Biomedical Imaging and BioengineeringBethesdaUSA

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