Molecular Imaging and Biology

, Volume 13, Issue 3, pp 573–576

Clinical Utility of Positron Emission Tomography/Computed Tomography in Inflammatory Bowel Disease

Authors

  • Robert T. Lapp
    • Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health
  • Bret J. Spier
    • Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health
  • Scott B. Perlman
    • Department of Radiology, University of Wisconsin School of Medicine and Public Health
  • Christine J. Jaskowiak
    • Department of Radiology, University of Wisconsin School of Medicine and Public Health
    • Division of Gastroenterology and Hepatology, Department of Medicine, University of Wisconsin School of Medicine and Public Health
Research Article

DOI: 10.1007/s11307-010-0367-0

Cite this article as:
Lapp, R.T., Spier, B.J., Perlman, S.B. et al. Mol Imaging Biol (2011) 13: 573. doi:10.1007/s11307-010-0367-0

Abstract

Purpose

The clinical utility of positron emission tomography/computed tomography (PET/CT) in comparison to standard workup in patients with known or suspected inflammatory bowel disease (IBD) is unknown.

Procedures

Clinical data were collected on seven patients with known or suspected IBD undergoing PET/CT. Standard workup included history, physical exam, laboratory tests, colonoscopy and/or cross-sectional imaging. We divided the intestine into five regions [small bowel and four colon (ascending, transverse, descending and rectosigmoid)] and graded relative standard uptake values 0, 1, 2 or 3 by comparison to the liver, using a region-of-interest analysis (0 = no activity, 1 = liver, 2 and 3 = significant inflammation).

Results

In patients 1 and 2, PET/CT demonstrated more activity than we thought clinically present. The other patients avoided unnecessary escalation or initiation of IBD therapy based on PET/CT results. Compared with standard workup, all seven patients had superior results when therapeutic decisions were based on PET/CT.

Conclusions

We found PET/CT to be very useful in diagnosis and management in patients with known or suspected IBD.

Key words

Inflammatory Bowel DiseasePet/CTClinicalCrohn's colitisUlcerative Colitis

Copyright information

© Academy of Molecular Imaging and Society for Molecular Imaging 2010