, Volume 13, Issue 2, pp 342-347

Image-Derived Input Function from Cardiac Gated Maximum a Posteriori Reconstructed PET Images in Mice

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Abstract

Purpose

The purpose of this study was to determine if accurate image-derived input functions (IDIF) can be measured from cardiac gated positron emission tomography (PET) images reconstructed using ordered subset expectation maximization–maximum a posteriori (OSEM-MAP) without further correction.

Procedures

IDIFs from the left ventricle were measured from cardiac gated PET images reconstructed using OSEM-MAP with computed tomography (CT)-based attenuation correction for five C57/BL6 mice. The accuracy of the IDIF was tested against blood samples using Bland–Altman analysis.

Results

Image-derived blood radioactivity concentration values were not significantly different from sampled blood values at two late time points as determined by a paired t test (P = 0.97). Bland–Altman analysis revealed a mean difference of 0.06 μCi/ml (1%). Using kinetic analysis, the mean myocardial 2-deoxy-2-[18F]fluoro-d-glucose uptake rate constant based on the IDIF was comparable to values reported in the literature based on physical blood sampling.

Conclusions

Accurate IDIFs can be obtained non-invasively. Although reconstruction times are increased, no further spillover corrections are necessary for IDIFs derived from gated, OSEM-MAP reconstructed images with attenuation correction.