Molecular Imaging and Biology

, Volume 12, Issue 4, pp 443–451

High Impact of 18F-FDG-PET on Management and Prognostic Stratification of Newly Diagnosed Small Cell Lung Cancer

  • Arun Azad
  • Fiona Chionh
  • Andrew M. Scott
  • Szeting T. Lee
  • Sam U. Berlangieri
  • Shane White
  • Paul L. Mitchell
Research Article

DOI: 10.1007/s11307-009-0295-z

Cite this article as:
Azad, A., Chionh, F., Scott, A.M. et al. Mol Imaging Biol (2010) 12: 443. doi:10.1007/s11307-009-0295-z

Abstract

Purpose

We evaluated whether 18F-FDG-PET altered stage classification, management, and prognostic stratification of newly diagnosed small cell lung cancer (SCLC).

Procedures

We identified 46 consecutive patients undergoing staging positron emission tomography for SCLC from 1993–2008 inclusive. Updated survival data from the state Cancer Registry was available on 42 of 46 patients.

Results

PET altered stage classification in 12 of 46 (26%) patients. PET altered treatment modality in nine patients, and the target mediastinal radiation field in another three patients. Therefore, PET altered management in 12 of 46 (26%) patients. Patients with limited disease (LD) on pre-PET staging had significantly longer overall survival (OS) than those upstaged to extensive disease (ED; median 18.6 months versus 5.7 months; log-rank p < 0.0001). In patients with ED on pre-PET staging, those downstaged to LD by PET had significantly longer OS than those with ED on PET (median 10.9 months versus 5.9 months; log-rank p = 0.037).

Conclusion

PET had a major impact on stage classification, management, and prognostic stratification of newly diagnosed SCLC.

Key words

FDG-PETSmall cell lung cancerLung cancer stagingLung cancerPET

Copyright information

© Academy of Molecular Imaging 2009

Authors and Affiliations

  • Arun Azad
    • 1
  • Fiona Chionh
    • 1
  • Andrew M. Scott
    • 2
    • 3
    • 4
  • Szeting T. Lee
    • 2
    • 3
    • 4
  • Sam U. Berlangieri
    • 2
    • 3
  • Shane White
    • 1
    • 3
  • Paul L. Mitchell
    • 1
    • 3
  1. 1.Ludwig Institute Oncology Unit, Austin HealthHeidelbergAustralia
  2. 2.Centre for Positron Emission Tomography, Austin HealthMelbourneAustralia
  3. 3.Department of MedicineUniversity of Melbourne, Austin HealthMelbourneAustralia
  4. 4.Ludwig Institute for Cancer Research, Austin HealthHeidelbergAustralia