Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
The aim of this study was to correlate metabolic behavior of follicular lymphoma with proliferative index (Ki67).
Materials and Methods
Pre-treatment 2-deoxy-2-[F-18]fluoro-d-glucose positron emission tomography–computed tomography scans of 23 patients with pathologic diagnosis of follicular lymphoma were retrospectively analyzed together with Ki67. The maximal standardized uptake value (SUV) was measured and corrected to glucose level of 100 mg/dl over the biopsy region (BxSUV100) and at the highest tumor activity of the body (BmSUV100).
BxSUV100 was significantly correlated with Ki67 (p = 0.037). There was an increasing trend of metabolic activity across the pathologic grades of follicular lymphomas. BmSUV100 and BxSUV100 were also significantly different (p < 0.0005), suggesting potential pitfalls of sampling error by histology.
The increasing trend of metabolic activity across follicular lymphoma grades correlates with cellular proliferation. The metabolic information from positron emission tomography–computed tomography may offer another useful parameter in the management of follicular lymphomas.
- Kumar R, Maillard I, Schuster DJ et al (2004) Utility of fluorodeoxyglucose-PET imaging in the management of patients with Hodgkin’s and non-Hodgkin’s lymphomas. Radiol Clin North Am 42:1083–1100 CrossRef
- Burton C, Ell P, Linch D (2004) The role of PET imaging in lymphoma. Br J Haematol 126:772–784 CrossRef
- The Non-Hodgkin’s Lymphoma Classification Project (1997) A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin’s lymphoma. Blood 89:3909–3918
- Lu P (2005) Staging and classification of lymphoma. Semin Nucl Med 35:160–164 CrossRef
- Gerdes J, Schwab U, Lemke H et al (1983) Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31:13–20 CrossRef
- Bryant RJ, Banks PM, O’Malley DP (2006) Ki67 staining pattern as a diagnostic tool in the evaluation of lymphoproliferative disorders. Histopathology 48:505–515 CrossRef
- Wirth A, Foo M, Seymour JF et al (2008) Impact of 18F-fluorodeoxyglucose positron emission tomography on staging and management of early-stage follicular non-Hodgkin lymphoma. Int J Radiat Oncol Biol Phys 71:213–219
- Karam M, Novak L, Cyriac J et al (2006) Role of fluorine-18 fluoro-deoxyglucose positron emission tomography scan in the evaluation and follow-up of patients with low-grade lymphomas. Cancer 107:175–183 CrossRef
- Wong CYO, Thie J, Parling-Lynch KJ et al (2007) Investigating the existence of quantum metabolic values in non-Hodgkin’s lymphoma by F-18 FDG. Mol Imaging Biol 9(1):43–49 CrossRef
- Wong CYO, Thie J, Parling-Lynch KJ, Zakalik D, Margolis JH, Qing F, Fink-Bennett D, Nagle C (2005) Glucose-normalized standard uptake value (SUV) from F-18 FDG PET in classifying lymphomas. J Nucl Med 46(10):1659–1663
- Wohrer S, Jaeger U, Kletter K et al (2006) 18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading. Annals of Oncol 17:780–784 CrossRef
- Schoder H, Noy A, Gonen M et al (2005) Intensity of 18Fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin’s lymphoma. J Clin Oncol 23:4643–4651 CrossRef
- Allen-Auerbach M, Quon A, Weber WA et al (2004) Comparison between 2-deoxy-2-[(18)F]Fluoro-D-glucose positron-emission tomography and positron-emission tomography/computed tomography hardware fusion for staging of patients with lymphoma. Mol Imaging Biol 6:411–416 CrossRef
- Correlating Metabolic Activity with Cellular Proliferation in Follicular Lymphomas
Molecular Imaging and Biology
Volume 11, Issue 5 , pp 296-302
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Follicular lymphoma
- Bone marrow
- Industry Sectors
- Author Affiliations
- 1. Positron Diagnostic Center and Medical Cyclotron, Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI, USA
- 2. Department of Pathology, William Beaumont Hospital, Royal Oak, MI, USA
- 3. Department of Medical Oncology, William Beaumont Hospital, Royal Oak, MI, USA