Molecular Imaging and Biology

, 11:343

NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of 3′-Deoxy-3′-[18F]fluorothymidine (FLT) as a Marker of Proliferation in Patients with Recurrent Gliomas: Preliminary Efficacy Studies

  • Alexander M. Spence
  • Mark Muzi
  • Jeanne M. Link
  • Finbarr O’Sullivan
  • Janet F. Eary
  • John M. Hoffman
  • Lalitha K. Shankar
  • Kenneth A. Krohn
Research Article

DOI: 10.1007/s11307-009-0215-2

Cite this article as:
Spence, A.M., Muzi, M., Link, J.M. et al. Mol Imaging Biol (2009) 11: 343. doi:10.1007/s11307-009-0215-2

Abstract

Purpose

3′-Deoxy-3′-[18F]fluorothymidine ([18F]FLT) is being developed for imaging cellular proliferation. The goals were to explore the capacity of FLT-positron emission tomography (PET) to distinguish between recurrence and radionecrosis in gliomas and compare the results to those obtained with 2-fluoro-2-deoxy-d-glucose (FDG).

Procedures

Fifteen patients with tumor recurrence and four with radionecrosis, determined by clinical course and magnetic resonance imaging results, were studied by dynamic [18F]FLT-PET with arterial blood sampling. A two-tissue compartment four-rate constant model was used to determine metabolic flux (KFLT), blood to tissue transport (K1), and phosphorylation (k3). FDG-PET scans were obtained 75–90 min postinjection.

Results

KFLT and k3, but not K1 or k3/k2 + k3, reached significance for separating the recurrence from radionecrosis groups. Standardized uptake value and visual analyses of FLT or FDG images did not reach significance.

Conclusions

KFLT (flux) appears to distinguish recurrence from radionecrosis better than other parameters, FLT and FDG semiquantitative approaches, or visual analysis of images of either tracer.

Key Words

3′-[18F]fluoro-3′-deoxythymidineFLTFluorothymidinePositron emission tomography (PET)GliomaRadionecrosisProliferation imaging

Copyright information

© Academy of Molecular Imaging 2009

Authors and Affiliations

  • Alexander M. Spence
    • 1
  • Mark Muzi
    • 2
  • Jeanne M. Link
    • 2
  • Finbarr O’Sullivan
    • 3
  • Janet F. Eary
    • 2
  • John M. Hoffman
    • 4
  • Lalitha K. Shankar
    • 5
  • Kenneth A. Krohn
    • 2
  1. 1.Department of NeurologyUniversity of WashingtonSeattleUSA
  2. 2.Department of RadiologyUniversity of WashingtonSeattleUSA
  3. 3.Department of StatisticsUniversity College CorkCorkIreland
  4. 4.Departments of Radiology and NeurologyUniversity of UtahSalt Lake CityUSA
  5. 5.Cancer Imaging Program, Division of Cancer Treatment and DiagnosisNational Cancer InstituteBethesdaUSA