Molecular Imaging and Biology

, Volume 10, Issue 5, pp 271–280

NCI-Sponsored Trial for the Evaluation of Safety and Preliminary Efficacy of FLT as a Marker of Proliferation in Patients with Recurrent Gliomas: Safety Studies

Authors

    • Department of NeurologyUniversity of Washington
  • Mark Muzi
    • Department of RadiologyUniversity of Washington
  • Jeanne M. Link
    • Department of RadiologyUniversity of Washington
  • John M. Hoffman
    • Departments of Radiology and NeurologyUniversity of Utah
  • Janet F. Eary
    • Department of RadiologyUniversity of Washington
  • Kenneth A. Krohn
    • Department of RadiologyUniversity of Washington
Research Article

DOI: 10.1007/s11307-008-0151-6

Cite this article as:
Spence, A.M., Muzi, M., Link, J.M. et al. Mol Imaging Biol (2008) 10: 271. doi:10.1007/s11307-008-0151-6
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Abstract

Purpose

3’-[F-18]Fluoro-3’-deoxythymidine (FLT) is an analog of thymidine that is being developed for imaging cellular proliferation. The goal of this study was to prove that the dose of FLT used for positron emission tomography imaging produces no significant toxicity.

Procedures

Twelve patients with gliomas with either recurrence or suspected radionecrosis were imaged with FLT. Before and at several time points after imaging, subjects underwent general physical and neurological examinations with review of systems and tests of hematologic, hepatic, renal, and several other metabolic parameters. Vital signs and electrocardiograms were monitored during and after the imaging session.

Results

There were no significant adverse effects from FLT injected at a dose of 0.07 mCi/kg (maximum of 5 mCi) at specific activities of 1.25 Ci/μmol or higher. The FLT mass administered for imaging was 0.0001% to 0.0009% of the least toxic cumulative dose administered in clinical trials of FLT as an antiretroviral agent.

Conclusions

FLT is a safe radiotracer for quantifying proliferation in the human cancer setting.

Key words

3’-[F-18]fluoro-3’-deoxythymidineFLTFluorothymidinePositron emission tomography (PET)GliomaGlioblastomaSafetyToxicityProliferation

Copyright information

© Academy of Molecular Imaging 2008