Molecular Imaging and Biology

, Volume 9, Issue 4, pp 217–222

Imaging Non-Dopaminergic Function in Parkinson’s Disease

Review Article Special Issue: Molecular Imaging in the Evaluation of Neurodegenerative Diseases

DOI: 10.1007/s11307-007-0084-5

Cite this article as:
Brooks, D.J. Mol Imaging Biol (2007) 9: 217. doi:10.1007/s11307-007-0084-5

Abstract

In Parkinson’s disease (PD), there is degeneration of the cholinergic, noradrenergic, and serotonergic systems in addition to dopaminergic projections. Function of these non-dopaminergic systems can be imaged with positron emission tomography (PET) and single photon emission computed tomography (SPECT) and correlated with motor and nonmotor symptomatology. In addition, neuronal loss in PD is associated with microglial activation. The role of microglia in driving the disease process remains uncertain. This review presents and discusses current findings in these areas.

Key words

Positron emission tomography Parkinson’s disease Acetylcholine Serotonin Noradrenaline Microglia 

Copyright information

© Academy of Molecular Imaging 2007

Authors and Affiliations

  1. 1.MRC Clinical Sciences Centre and Division of Neuroscience and Mental Health, Faculty of MedicineImperial College, Hammersmith HospitalLondonUK
  2. 2.Imperial College London, Cyclotron BuildingHammersmith HospitalLondonUK

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