Molecular Imaging and Biology

, Volume 8, Issue 1, pp 43–48

Positron Emission Tomography/Computed Tomography with F-18-fluorocholine for Restaging of Prostate Cancer Patients: Meaningful at PSA < 5 ng/ml?

  • Martin Heinisch
  • Albert Dirisamer
  • Wolfgang Loidl
  • Franz Stoiber
  • Bernhard Gruy
  • Silke Haim
  • Werner Langsteger
Original Article

DOI: 10.1007/s11307-005-0023-2

Cite this article as:
Heinisch, M., Dirisamer, A., Loidl, W. et al. Mol Imaging Biol (2006) 8: 43. doi:10.1007/s11307-005-0023-2

Abstract

 

According to reports, re-staging of patients suffering from prostate cancer by positron emission tomography (PET) using C-11-choline has failed to produce positive findings at a PSA level of < 5 ng/ml. Hence, the purpose of our study has been to determine whether this is true also for PET/CT using F-18-fluorocholine (FCH PET/CT) or whether it is possible to obtain true positive results by FCH PET/CT even at lower PSA levels.

Methods

In 34 patients with prostate cancer who had undergone initial therapy (radical prostatectomy n = 31, radiotherapy n = 3), a PET/CT scan was performed using F-18-fluorocholine (FCH) during follow-up in case of demonstrable or rising PSA levels. Current PSA levels were determined in all patients at the time of examination.

Results

Median PSA in FCH positive patients was 6.1 ng/ml (mean PSA 17.1 ng/ml), median PSA in FCH negative patients was 2.3 ng/ml (mean PSA 3.4 ng/ml), respectively (p < 0.05). In eight of 17 examinations (47%) with PSA < 5 ng/ml, at least one FCH-positive focus was detected. So far the findings could be confirmed by correlating imaging methods (CT and/or MR), biopsy/histology and the course of the disease, respectively, in seven of the eight FCH-positive cases with PSA < 5 ng/ml, so that a true positive FCH PET/CT finding was obtained all in all in seven of 17 (41%) examinations with PSA < 5 ng/ml. In four of these seven FCH PET-positive patients with PSA < 5 ng/ml, adjuvant hormonal therapy was administered at the time of the examination or prior to the examination.

Conclusion

In re-staging patients with prostate cancer, FCH PET/CT is able to yield true positive findings even at PSA < 5 ng/ml. Therefore, FCH PET/CT should not be restricted to patients with PSA > 5 ng/ml.

Key words

F-18-fluorocholinePET/CTRestaging of prostate cancerProstate specific antigen (PSA)

Copyright information

© Academy of Molecular Imaging 2005

Authors and Affiliations

  • Martin Heinisch
    • 1
  • Albert Dirisamer
    • 2
  • Wolfgang Loidl
    • 3
  • Franz Stoiber
    • 3
  • Bernhard Gruy
    • 1
  • Silke Haim
    • 1
  • Werner Langsteger
    • 1
  1. 1.Department of Nuclear Medicine, PET Center LinzSt. Vincent’s Hospital LinzLinzAustria
  2. 2.Department of RadiologyUniversity Hospital ViennaViennaAustria
  3. 3.Department of UrologySt. Vincent's Hospital LinzLinzAustria