, Volume 9, Issue 2, pp 497–505

The use of metabolomics as a tool to investigate hepatitis C


    • Department of Biochemistry, School of Environmental and Health SciencesNorth-West University
  • Nomathamsanqa P. Sithebe
    • School of Environmental and Health SciencesNorth-West University
Review Article

DOI: 10.1007/s11306-012-0467-8

Cite this article as:
du Preez, I. & Sithebe, N.P. Metabolomics (2013) 9: 497. doi:10.1007/s11306-012-0467-8


According to World Health Organization, an estimated 3 % of the global population is suffering from chronic hepatitis C. Furthermore, 60–70 % of chronically-infected patients develop liver diseases, of which 5–20 % of all cases advance to cirrhosis, and 1–5 % die from hepatitis C related hepatocellular carcinoma. This high incidence might be ascribed to the poor performance of the currently available diagnostic, treatment, and vaccination protocols, together with the lack of knowledge of the underlying disease mechanisms. In this review, we discuss the role that the relatively new research field termed metabolomics, alone or as part of an integrated ‘omics’ approach, has played in the investigation of hepatitis C and associated clinical manifestations. We also consider future research possibilities in this field, and the impact that these results might have on the fight against this global health predicament.


MetabolomicsHepatitis CLiver fibrosisHepatocellular carcinoma

Copyright information

© Springer Science+Business Media New York 2012