Metabolomics

, Volume 8, Issue 6, pp 1204–1217

Metabolome analysis during the morphological transition of Candida albicans

  • Ting-li Han
  • Richard D. Cannon
  • Silas G. Villas-Bôas
Original Article

DOI: 10.1007/s11306-012-0416-6

Cite this article as:
Han, T., Cannon, R.D. & Villas-Bôas, S.G. Metabolomics (2012) 8: 1204. doi:10.1007/s11306-012-0416-6

Abstract

Candida albicans is an opportunistic pathogen of humans with significant mortality in severely immunocompromised patients. The ability to switch from yeast to hyphal morphology and vice versa, in response to various environmental cues, is believed to be a critical virulence factor of this fungus. However, the mechanisms that recognize such environmental signals and trigger the morphological change at a system level are still not clearly understood. Therefore, we have compared the metabolite profiles of C. albicans cells growing under different hyphae-inducing conditions to the metabolite profiles of growing yeast cells. Surprisingly our results suggest an overall downregulation of cellular metabolism during the yeast to hyphal morphological transition. Among the metabolic pathways involved in the central carbon metabolism, we have found seventeen that were significantly downregulated in all three hyphae-inducing conditions. This indicates that these central carbon metabolic pathways are likely to be intrinsically involved in the downstream effects of the morphogenetic process.

Keywords

Candida albicans Metabolite profiling Central carbon metabolism Metabolomics Filamentous growth Morphogenesis 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Ting-li Han
    • 1
  • Richard D. Cannon
    • 2
  • Silas G. Villas-Bôas
    • 1
  1. 1.Centre for Microbial Innovation, School of Biological SciencesThe University of AucklandAucklandNew Zealand
  2. 2.Department of Oral SciencesUniversity of OtagoDunedinNew Zealand

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