Metabolic acidosis and the importance of balanced equations
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- Lane, A.N., Fan, T.WM. & Higashi, R.M. Metabolomics (2009) 5: 163. doi:10.1007/s11306-008-0142-2
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Balancing biochemical equations for both mass and charge in metabolic networks is critical but unfortunately ignored too often. Failure to do so, for example, results in a common misconception about the origin of protons during lactic fermentation. Lactate, rather than lactic acid, is produced by glycolysis, and its production is a mechanism for alleviating intracellular acidosis due to glycolysis. This error is at the core of some recent papers, and is often ambiguous in biochemistry textbooks.