Purinergic Signalling

, Volume 9, Issue 3, pp 285–306

Purinergic signaling in inflammatory cells: P2 receptor expression, functional effects, and modulation of inflammatory responses

  • Fenila Jacob
  • Claudina Pérez Novo
  • Claus Bachert
  • Koen Van Crombruggen
Review Article

DOI: 10.1007/s11302-013-9357-4

Cite this article as:
Jacob, F., Novo, C.P., Bachert, C. et al. Purinergic Signalling (2013) 9: 285. doi:10.1007/s11302-013-9357-4

Abstract

Extracellular ATP and related nucleotides promote a wide range of pathophysiological responses via activation of cell surface purinergic P2 receptors. Almost every cell type expresses P2 receptors and/or exhibit regulated release of ATP. In this review, we focus on the purinergic receptor distribution in inflammatory cells and their implication in diverse immune responses by providing an overview of the current knowledge in the literature related to purinergic signaling in neutrophils, macrophages, dendritic cells, lymphocytes, eosinophils, and mast cells. The pathophysiological role of purinergic signaling in these cells include among others calcium mobilization, actin polymerization, chemotaxis, release of mediators, cell maturation, cytotoxicity, and cell death. We finally discuss the therapeutic potential of P2 receptor subtype selective drugs in inflammatory conditions.

Keywords

ATP Extracellular nucleotides P2 receptors Inflammatory cells Regulation of immune responses 

Abbreviations

cAMP

Cyclic adenosine monophosphate

DCs

Dendritic cells

ECP

Eosinophil cationic protein

ERK

Extracellular signal-regulated kinases

fMLP

fMet-Leu-Phe receptor

HLMC

Human lung mast cell

HMC

Human mast cell

IP3

Inositol 1,4,5-triphosphate

LAD 2

Leukocyte adhesion deficiency

LCL

Lymphoblastoid cell lines

MIP-2

Macrophage inflammatory protein-2

MoDCs

Monocyte-derived dendritic cells

MSU

Monosodium urate

E-NTPDase1

Ecto-nucleoside triphosphate diphosphohydrolase 1

PLC

Phospholipase C

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Fenila Jacob
    • 1
  • Claudina Pérez Novo
    • 1
  • Claus Bachert
    • 1
  • Koen Van Crombruggen
    • 1
  1. 1.Upper Airways Research Laboratory, Department of OtorhinolaryngologyGhent University HospitalGhentBelgium

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