Purinergic Signalling

, Volume 8, Issue 1, pp 15–22

Expression of P2X2 and P2X3 receptors in the rat carotid sinus, aortic arch, vena cava, and heart, as well as petrosal and nodose ganglia

Original Article

DOI: 10.1007/s11302-011-9249-4

Cite this article as:
Song, X., Gao, X., Guo, D. et al. Purinergic Signalling (2012) 8: 15. doi:10.1007/s11302-011-9249-4

Abstract

With single- and double-labeling immunofluorescence techniques, the distribution patterns and morphological characteristics of P2X2- and P2X3-immunoreactive nerve fiber terminals and neuronal bodies have been studied in the main circulatory system baroreceptors and the nodose and petrosal ganglia of rats. A high density of P2X2- and P2X3-immunoreactive nerve fiber terminals was detected in the carotid sinus. P2X2- and P2X3-immunoreactive nerve fiber terminals were also distributed widely in the aortic arch, atrium, vena cava, and ventricles. Almost all the P2X2-immunoreactive nerve fiber terminals were immunoreactive for P2X3 receptors. P2X2- and P2X3-immunoreactive neuronal bodies were also detected in the nodose and petrosal ganglia, which are the sources of the P2X2- and P2X3-immunoreactive nerve terminals. P2X2 and P2X3 receptors were expressed in the same ganglionic neurons. These data indicate that extracellular ATP, via the homomeric P2X2 and P2X3 receptors, and heteromeric P2X2/3 receptor in the sensory receptors of carotid sinus, aortic arch, atrium, and vena cava, may be involved in the regulation of systematic circulation blood pressure.

Keywords

PurinoceptorBaroreceptorImmunohistochemistryRat

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Xianmin Song
    • 1
  • Xiaofei Gao
    • 1
  • Dazhi Guo
    • 1
  • Qiang Yu
    • 1
  • Wei Guo
    • 1
  • Cheng He
    • 1
  • Geoffrey Burnstock
    • 2
  • Zhenghua Xiang
    • 1
  1. 1.Department of Neurobiology, Key Laboratory of Molecular Neurobiology, Ministry of Education, Neuroscience Research Centre of Changzheng HospitalSecond Military Medical UniversityShanghaiPeople’s Republic of China
  2. 2.Autonomic Neuroscience CentreUniversity College Medical School, Royal Free CampusLondonUK