, Volume 6, Issue 1, pp 49-115

Third joint Italian-German Purine Club meeting: “Purinergic receptors: new frontiers for novel therapies”

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Invited Lectures Abstracts

Purinergic signalling: some exciting new directions

Geoffrey Burnstock

Autonomic Neuroscience Centre, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK

Presenting author: g.burnstock@ucl.ac.uk

After a brief initial description of some of the important steps in the establishment of purinergic signalling, the talk will focus on some of the exciting new directions in the field, particularly those relating to purinergic pathophysiology and potential therapeutic applications. There will be discussion of the long-term trophic effects of purines and pyrimidines in blood vessel remodelling in restenosis; plasticity of purinergic cotransmission of diseased urinary bladder; hypertensive rats; sperm motility in IVF; purinergic mechanosensory transduction in visceral pain and the role of spinal microglial purinoceptors in neuropathic pain; the potential for P2X7 receptor antagonists in osteoporosis and kidney failure and the growing lit