Purinergic Signalling

, Volume 5, Issue 3, pp 273–275

Prostatic acid phosphatase, a neglected ectonucleotidase

Brief Communication

DOI: 10.1007/s11302-009-9157-z

Cite this article as:
Zimmermann, H. Purinergic Signalling (2009) 5: 273. doi:10.1007/s11302-009-9157-z


Two recent papers reveal that the soluble and secreted prostatic acid phosphatase, an enzyme that has long served as a diagnostic marker for prostate cancer, has a membrane-bound splice variant. This enzyme exhibits ecto-5′-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. While prostatic acid phosphatase hydrolyzes phosphomonoesters other than 5′-nucleoside monophosphates these novel data suggest that, in addition to ecto-5′-nucleotidase and the alkaline phosphatases, prostatic acid phosphatase must be taken into account in future studies on extracellular adenosine production.


Ecto-5′-nucleotidaseProstatic acid phosphataseAlkaline phosphatasePain

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Institute of Cell Biology and NeuroscienceBiocenter, Goethe-UniversityFrankfurtGermany