World Journal of Microbiology and Biotechnology

, Volume 27, Issue 5, pp 1083–1089

Hypolipidemic and antioxidant properties of Ganoderma lucidum (Leyss:Fr) Karst used as a dietary supplement

  • Rosália Rubel
  • Herta S. Dalla Santa
  • Luiz Cláudio Fernandes
  • Sandro J. R. Bonatto
  • Sérgio Bello
  • Bonald C. Figueiredo
  • José Hermenio C. Lima Filho
  • Cid Aimbiré M. Santos
  • Carlos Ricardo Soccol
Original Paper

DOI: 10.1007/s11274-010-0554-9

Cite this article as:
Rubel, R., Dalla Santa, H.S., Fernandes, L.C. et al. World J Microbiol Biotechnol (2011) 27: 1083. doi:10.1007/s11274-010-0554-9

Abstract

In this study, the hypolipidemic and antioxidant properties of Ganoderma lucidum CG 144, a medicinal mushroom cultivated on wet wheat grains by solid-state fermentation, were investigated followed dietary supplementation. Basal chow was supplemented with 85, 50, or 10% of G. lucidum CG 144 dried spawn, resulting in G85, G50, and G10 diets, respectively, and fed to normocholesterolemic and induced-hypercholesterolemic mice. The G85 diet triggered significant loss of body weight compared with the G50 and G10 diets (P < 0.01). In the normocholesterolemic mice, regular consumption of high concentrations (G85 and G50 diets) of dried spawn led to significant changes in the plasma lipid concentrations (P < 0.05). Although there were no significant changes in the plasma cholesterol concentrations, the G85 and G50 diets decreased the low-density-lipoprotein (LDL) cholesterol levels by 71 and 98%, respectively, and increased the high-density-lipoprotein (HDL) cholesterol levels by 80 and 86%, respectively. Further, the plasma triacylglycerol levels decreased by 32.5 and 42% with the G85 and G50 diets, respectively. The G10 diet did not alter the plasma lipid profile in the normocholesterolemic mice (P > 0.05) but significantly decreased the cholesterol concentrations (P < 0.001) in the induced-hypercholesterolemic mice. Peritoneal macrophages from the induced-hypercholesterolemic mice fed the G10 diet produced lower nitric oxide than the controls (P < 0.05).

Keywords

Ganoderma lucidumMedicinal mushroomCholesterolNitric oxideAntioxidant

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Rosália Rubel
    • 1
  • Herta S. Dalla Santa
    • 1
  • Luiz Cláudio Fernandes
    • 2
  • Sandro J. R. Bonatto
    • 2
  • Sérgio Bello
    • 2
  • Bonald C. Figueiredo
    • 3
  • José Hermenio C. Lima Filho
    • 4
  • Cid Aimbiré M. Santos
    • 5
  • Carlos Ricardo Soccol
    • 1
    • 6
  1. 1.Bioprocess Engineering and Biotechnology DivisionFederal University of Paraná (UFPR)CuritibaBrazil
  2. 2.Department of PhysiologyUFPRCuritibaBrazil
  3. 3.Pelé Pequeno Príncipe Research InstituteCuritibaBrazil
  4. 4.Department of Medical PathologyUFPRCuritibaBrazil
  5. 5.Pharmacognosie Laboratory, Department of PharmacyUFPRCuritibaBrazil
  6. 6.Divisão de Engenharia de Bioprocessos & Biotecnologia Industrial, Departamento de Engenharia Química, Centro PolitécnicoUniversidade Federal do ParanáCuritibaBrazil